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Literature summary extracted from

  • Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S.
    Fatty acid synthesis in mitochondria of Euglena gracilis (1984), Eur. J. Biochem., 142, 121-126.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.8 cytosol
-
 Euglena gracilis 5829
-
1.3.1.8 microsome
-
 Euglena gracilis
-
-
1.3.1.8 mitochondrion soluble fraction of mitochondria Euglena gracilis 5739
-
1.3.1.44 mitochondrion
-
 Euglena gracilis 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.8 additional information Euglena gracilis active as part of fatty acid synthetase by incorporation of acetyl-CoA in mitochondria and of malonyl-CoA in cytosol ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.8 Euglena gracilis
-
 3 different enzyme isoforms I, II and III, not exactly differentiated concerning elongation system I and II
-
1.3.1.44 Euglena gracilis
-
 reductase I,II and III
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.8 2-trans-decenoyl-CoA + NAD(P)H mitochondrial reductase II shows high activity, cofactor NADH Euglena gracilis decanoyl-CoA + NADP+
-
 ?
1.3.1.8 2-trans-dodecenoyl-CoA + NAD(P)H mitochondrial reductases II and III, low activity, cofactor NADH for isoform II and NADH or NADPH for isoform III Euglena gracilis dodecanoyl-CoA + NAD(P)+
-
 ?
1.3.1.8 2-trans-hexenoyl-CoA + NAD(P)H mitochondrial enzymes, reductase III shows highest activity, reductase I shows 45% activity of that with crotonyl-CoA, reductase II shows lower activity, cofactor NADH for isoform I and II and NADH or NADPH for isoform III Euglena gracilis hexanoyl-CoA + NADP+
-
 ?
1.3.1.8 2-trans-octadecenoyl-CoA + NAD(P)H cofactor NADH, mitochondrial reductase I shows 25% activity of that with crotonyl-CoA, reductase II shows highest activity Euglena gracilis octadecanoyl-CoA + NAD(P)+
-
 ?
1.3.1.8 2-trans-octenoyl-CoA + NAD(P)H mitochondrial enzyme, NADH-specific reaction Euglena gracilis octanoyl-CoA + NADP+
-
 ?
1.3.1.8 crotonyl-CoA + NAD(P)H mitochondrial reductase I, no specification of stereoisomer, cofactor NADH Euglena gracilis butanoyl-CoA + NADP+
-
 ?
1.3.1.8 additional information mitochondrial reductase III uses substrate with chain length of C4-C12 Euglena gracilis ?
-
 ?
1.3.1.8 additional information no cis-isomeric substrates tested, classification is not definite Euglena gracilis ?
-
 ?
1.3.1.8 additional information active as part of fatty acid synthetase by incorporation of acetyl-CoA in mitochondria and of malonyl-CoA in cytosol Euglena gracilis ?
-
 ?
1.3.1.44 crotonyl-CoA + NADH reductase I highest activity Euglena gracilis butyryl-CoA + NAD+
-
 ?
1.3.1.44 additional information reductase isoforms are chain length-specific Euglena gracilis ?
-
 ?
1.3.1.44 trans-2-decenoyl-CoA + NADH reductase II: highest activity Euglena gracilis decanoyl-CoA + NAD+
-
 ?
1.3.1.44 trans-2-hexenoyl-CoA + NAD(P)H reductase III: highest activity, utilizes substrates of chain length C4-C12 Euglena gracilis hexanoyl-CoA + NAD(P)+
-
 ?
1.3.1.44 trans-2-octenoyl-CoA + NADH reductase II: highest activity Euglena gracilis octanoyl-CoA + NAD+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.8 NADH reductases I and II Euglena gracilis
1.3.1.8 NADPH reductase III Euglena gracilis
1.3.1.44 NADH
-
 Euglena gracilis
1.3.1.44 NADPH enzyme utilizes NADH and NADPH depending on chain length, with NADPH a C-6 substrate is preferred, with NADH a C-8 substrate is preferred Euglena gracilis