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Literature summary extracted from

  • Mahler, H.R.
    Studies on the fatty acid oxidization system of animal tissues. IV. The prosthetic group of butyryl coenzyme A dehydrogenase (1954), J. Biol. Chem., 206, 13-26.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.8.1 CN- activates the enzyme in reaction with ferricytochrome c or ferricyanide as electron acceptors, but not with flavin D or FAd Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.8.1 4-chloromercuribenzoate 0.1 mM, 40% inhibition Bos taurus
1.3.8.1 4-chloromercuribenzoate inhibition is reversible by glutathione Sus scrofa
1.3.8.1 Hg2+
-
Sus scrofa
1.3.8.1 additional information no inhibition by CN- Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.8.1 copper 2 mol copper /mol FAD, cupric ion can be removed by dialysis against cyanide, copper is not involved in redox reaction Bos taurus
1.3.8.1 Cu2+ 10-12 copper ions per enzyme molecule, enzyme-bound copper. The Cu2+ does not play a role in the primary reduction of the flavin-bound enzyme Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.8.1 120000 220000 gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.8.1 butanoyl-CoA + oxidized acceptor Sus scrofa
-
crotonyl-CoA + reduced acceptor
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.1 Bos taurus
-
-
-
1.3.8.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.8.1 kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.1 butanoyl-CoA + oxidized acceptor
-
Sus scrofa crotonyl-CoA + reduced acceptor
-
r
1.3.8.1 additional information no activity with octanoyl-CoA and acetyl-CoA Sus scrofa ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.3.8.1 butyryl CoA dehydrogenase
-
Sus scrofa
1.3.8.1 butyryl coenzyme A dehydrogenase
-
Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.8.1 25 38 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.8.1 7
-
assay at Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.8.1 FAD about 5 or 6 FAD molecules per enzyme molecule Bos taurus
1.3.8.1 FAD enzyme-bound, flavin D Sus scrofa
1.3.8.1 ferricytochrome c
-
Sus scrofa
1.3.8.1 riboflavin enzyme-bound Sus scrofa