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Literature summary extracted from

  • Baker, B.R.
    Tissue-specific irreversible inhibitors of dihydrofolic reductase (1969), Acc. Chem. Res., 2, 129-136.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 additional information overview Mus musculus
1.5.1.3 additional information overview Pigeon
1.5.1.3 additional information overview Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Mus musculus
-
 overview
-
1.5.1.3 Pigeon
-
 overview
-
1.5.1.3 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.5.1.3 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ inhibitor binding mechanism Mus musculus
a
1.5.1.3 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ inhibitor binding mechanism Rattus norvegicus
a
1.5.1.3 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ inhibitor binding mechanism Pigeon
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.3 intestine
-
 Mus musculus
-
1.5.1.3 L-1210 cell
-
 Mus musculus
-
1.5.1.3 liver
-
 Mus musculus
-
1.5.1.3 liver
-
 Rattus norvegicus
-
1.5.1.3 liver
-
 Pigeon
-
1.5.1.3 LLC-WRC 256 cell tumor cell line Rattus norvegicus
-
1.5.1.3 spleen
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 7,8-dihydrofolate + NADPH
-
 Mus musculus 5,6,7,8-tetrahydrofolate + NADP+
-
 ir
1.5.1.3 7,8-dihydrofolate + NADPH
-
 Rattus norvegicus 5,6,7,8-tetrahydrofolate + NADP+
-
 ir
1.5.1.3 7,8-dihydrofolate + NADPH
-
 Pigeon 5,6,7,8-tetrahydrofolate + NADP+
-
 ir

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.3 NADPH
-
 Mus musculus
1.5.1.3 NADPH
-
 Rattus norvegicus
1.5.1.3 NADPH
-
 Pigeon