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Literature summary extracted from

  • Cella, R.; Parisi, B.
    Dihydrofolate reductase and thymidylate synthase in plants: An open problem (1993), Physiol. Plant., 88, 509-521.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 additional information
-
Crithidia fasciculata
1.5.1.3 additional information overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants Datura inoxia
1.5.1.3 additional information overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants Daucus carota
1.5.1.3 additional information overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants Glycine max
1.5.1.3 additional information overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants Nicotiana plumbaginifolia
1.5.1.3 additional information overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants Nicotiana tabacum
1.5.1.3 additional information overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants Petunia x hybrida
1.5.1.3 additional information
-
Tetradesmus obliquus
1.5.1.3 additional information overview antifolate inhibitors, especially methotrexate, and sensitivity or resistance in plants Zea mays

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.3 additional information
-
additional information
-
Leishmania tropica
1.5.1.3 additional information
-
additional information overview Tetradesmus obliquus
1.5.1.3 additional information
-
additional information overview Pisum sativum
1.5.1.3 additional information
-
additional information overview Glycine max
1.5.1.3 additional information
-
additional information overview Crithidia fasciculata
1.5.1.3 additional information
-
additional information overview Daucus carota
1.5.1.3 additional information
-
additional information overview Oryza sativa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.5.1.3 additional information
-
overview Tetradesmus obliquus
1.5.1.3 additional information
-
overview Glycine max
1.5.1.3 additional information
-
overview Crithidia fasciculata
1.5.1.3 additional information
-
overview Daucus carota
1.5.1.3 additional information
-
overview Leishmania tropica

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Crithidia fasciculata
-
-
-
1.5.1.3 Datura inoxia
-
-
-
1.5.1.3 Daucus carota
-
-
-
1.5.1.3 Euglena gracilis
-
-
-
1.5.1.3 Glycine max
-
-
-
1.5.1.3 Leishmania tropica
-
-
-
1.5.1.3 Nicotiana plumbaginifolia
-
-
-
1.5.1.3 Nicotiana tabacum
-
-
-
1.5.1.3 Oryza sativa
-
-
-
1.5.1.3 Petunia x hybrida
-
-
-
1.5.1.3 Pisum sativum
-
-
-
1.5.1.3 Tetradesmus obliquus
-
-
-
1.5.1.3 Zea mays
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.3 overview Tetradesmus obliquus
1.5.1.3 overview Glycine max
1.5.1.3 overview Daucus carota

Reaction

EC Number Reaction Comment Organism Reaction ID
1.5.1.3 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ bifunctional proteins with DHFR and thymidylate synthase activity Tetradesmus obliquus
1.5.1.3 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ bifunctional proteins with DHFR and thymidylate synthase activity Crithidia fasciculata
1.5.1.3 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ bifunctional proteins with DHFR and thymidylate synthase activity Daucus carota

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.3 seedling
-
Pisum sativum
-
1.5.1.3 seedling
-
Glycine max
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.3 additional information
-
-
Leishmania tropica
1.5.1.3 additional information
-
overview Glycine max
1.5.1.3 additional information
-
overview Daucus carota

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 7,8-dihydrofolate + NADPH
-
Tetradesmus obliquus 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Euglena gracilis 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Pisum sativum 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Zea mays 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Nicotiana tabacum 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Glycine max 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Crithidia fasciculata 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Datura inoxia 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Daucus carota 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Oryza sativa 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Petunia x hybrida 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Nicotiana plumbaginifolia 5,6,7,8-tetrahydrofolate + NADP+
-
r
1.5.1.3 7,8-dihydrofolate + NADPH
-
Leishmania tropica 5,6,7,8-tetrahydrofolate + NADP+
-
r

Subunits

EC Number Subunits Comment Organism
1.5.1.3 dimer
-
Tetradesmus obliquus
1.5.1.3 dimer
-
Crithidia fasciculata
1.5.1.3 dimer
-
Leishmania tropica
1.5.1.3 More overview Tetradesmus obliquus
1.5.1.3 More overview Glycine max
1.5.1.3 More overview Daucus carota
1.5.1.3 More bifunctional, homodimers with DHFR and TS domains for each monomer Crithidia fasciculata
1.5.1.3 More bifunctional, homodimers with DHFR and TS domains for each monomer Leishmania tropica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.3 additional information
-
overview Tetradesmus obliquus
1.5.1.3 additional information
-
overview Pisum sativum
1.5.1.3 additional information
-
overview Glycine max
1.5.1.3 additional information
-
overview Daucus carota
1.5.1.3 additional information
-
overview Oryza sativa