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Literature summary extracted from

  • Case, G.L.; Kaisaki, P.J.; Steele, R.D.
    Resolution of rat liver 10-formyltetrahydrofolate dehydrogenase/hydrolase activities (1988), J. Biol. Chem., 263, 10204-10207.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.6 0.001
-
 NADP+
-
 Rattus norvegicus
1.5.1.6 0.017
-
 10-formyltetrahydrofolate racemic Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.1.6 cytosol primarily or exclusively localized in Rattus norvegicus 5829
-
1.5.1.6 mitochondrion small amount, 0.4% of total liver dehydrogenase activity Rattus norvegicus 5739
-
1.5.1.6 additional information not detected in nucleus, lysosomes or peroxisomes Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.5.1.6 94000
-
 x * 94000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.6 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.6 separated from 10-formyltetrahydrofolate hydrolase, dehydrogenase and hydrolase are closely related and separately compartmentalized enzymes Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.6 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.6 0.347
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.6 10-formyltetrahydrofolate + NADP+ + H2O specific for NADP+ Rattus norvegicus tetrahydrofolate + CO2 + NADPH + H+
-
 ?
1.5.1.6 additional information 10-formyltetrahydrofolate dehydrogenase and hydrolase are closely related and separately compartmentalized enzymes Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.5.1.6 ? x * 94000, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.1.6 30
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.6 10-formyltetrahydrofolate 10-formyltetrahydrofolate Rattus norvegicus
1.5.1.6 NADP+ NADP+-dependent Rattus norvegicus
1.5.1.6 tetrahydrofolate
-
 Rattus norvegicus