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Literature summary extracted from

  • Wittwer, A.J.; Wagner, C.
    Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins (1981), J. Biol. Chem., 256, 4109-4115.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.8.4 Dimethylthetin
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.8.3 0.32 1 sarcosine
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.8.3 mitochondrion
-
Rattus norvegicus 5739
-
1.5.8.4 mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.8.3 sarcosine + acceptor + H2O Rattus norvegicus acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate glycine + formaldehyde + reduced acceptor
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.5.8.3 Rattus norvegicus
-
-
-
1.5.8.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.8.3 liver
-
Rattus norvegicus
-
1.5.8.4 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.8.3 sarcosine + acceptor + H2O acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate Rattus norvegicus glycine + formaldehyde + reduced acceptor
-
?
1.5.8.4 epsilon-N-methyl-L-lysine + acceptor + H2O
-
Rattus norvegicus formaldehyde + L-lysine + reduced acceptor
-
?
1.5.8.4 N,N-dimethylglycine + acceptor + H2O acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate Rattus norvegicus sarcosine + formaldehyde + reduced acceptor
-
?
1.5.8.4 N,N-dimethylglycine + acceptor + H2O bound tetrahydrofolate interacts directly with the enzyme and serves as an acceptor for the one-carbon unit produced during the oxidative demethylation of dimethylglycine Rattus norvegicus sarcosine + formaldehyde + reduced acceptor
-
?
1.5.8.4 N-methyl-L-alanine + acceptor + H2O
-
Rattus norvegicus formaldehyde + L-alanine + reduced acceptor
-
?
1.5.8.4 sarcosine + acceptor + H2O
-
Rattus norvegicus glycine + formaldehyde + reduced acceptor
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.8.3 FAD covalent bound FAD linked via 8a-position of the isoalloxazin ring to the imidazole N(3) of a histidine residue, structural homology between the amino acid sequence of the flavin-peptides Rattus norvegicus
1.5.8.3 tetrahydrofolate
-
Rattus norvegicus
1.5.8.4 FAD covalently bound Rattus norvegicus