Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ushakova, A.V.; Grivennikova, V.G.; Ohnishi, T.; Vinogradov, A.D.
    Triton X-100 as a specific inhibitor of the mammalian NADH-ubiquinone oxidoreductase (Complex I) (1999), Biochim. Biophys. Acta, 1409, 143-153.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 Triton X-100 specific inhibitor of ubiquinone reduction by complex I Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 additional information submitochondrial particles Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Bos taurus
-
 rotenone-sensitive enzyme complex
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?
7.1.1.2 NADH + ubiquinone-1
-
 Bos taurus NAD+ + ubiquinol-1
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
7.1.1.2 additional information
-
 Triton X-100 partially protects complex I against thermally induced deactivation and partially activates the thermally deactivated enzyme Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
7.1.1.2 0.01
-
 Triton X-100 pH 8.0, 25°C Bos taurus