Literature summary extracted from

Fujita, S.; Peisach, J.
The stimulation of microsomal azoreduction by flavins (1982), Biochim. Biophys. Acta, 719, 178-189.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.7.1.6	FMN	increases activity	Rattus norvegicus
1.7.1.6	methylviologen	activation	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.7.1.6	CO	noncompetitive vs. amaranth	Rattus norvegicus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.7.1.6	0.00645	-	CO	-	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.7.1.6	endoplasmic reticulum	i.e. microsomes	Rattus norvegicus	5783	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.7.1.6	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.7.1.6	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.7.1.6	1-(4-sulfo-1-naphthylazo)-2-naphthol-3,6-disulfonic acid + NADPH	trivial name amaranth, activity in liver microsomes	Rattus norvegicus	alpha-naphthylamine-4-sulfonic acid + beta-naphthol-3,6-disulfonic acid + NADP+	-	?
1.7.1.6	4-(dimethylamino)azobenzene + 2 NADPH	-	Rattus norvegicus	N,N-dimethyl-1,4-phenylenediamine + aniline + 2 NADP+ + 2 H+	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.7.1.6	FAD	increases activity	Rattus norvegicus
1.7.1.6	NADPH	-	Rattus norvegicus
1.7.1.6	riboflavin	activation	Rattus norvegicus

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.7.1.6	0.006	-	CO	-	Rattus norvegicus

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Release 2023.1 (January 2023)