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Literature summary extracted from

  • Fasco, M.J.; Principe, L.M.
    Vitamin K1 hydroquinone formation catalyzed by DT-diaphorase (1982), Biochem. Biophys. Res. Commun., 104, 187-192.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.2 3,3'-methylene-bis(4-hydroxycoumarin) competitive vs. NADH, uncompetitive vs. vitamin K1 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.5.2 0.002
-
 menadione
-
 Rattus norvegicus
1.6.5.2 0.0175
-
 NADH
-
 Rattus norvegicus
1.6.5.2 0.0233
-
 oxidized 2,6-dichlorophenolindophenol
-
 Rattus norvegicus
1.6.5.2 0.0305
-
 NADH in the presence of 0.026 mM dicoumarol Rattus norvegicus
1.6.5.2 0.0641
-
 vitamin K1
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.5.2 quinone + NAD(P)H Rattus norvegicus protection of cells against damage by reactive oxygen species generated during oxidative cycling of quinones and semiquinone radicals hydroquinone + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Rattus norvegicus
-
 3 to 4fold induction by 3-methylcholanthrene
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 2-methyl-1,4-naphthoquinone + NAD(P)H artificial acceptor, trivial name menadione Rattus norvegicus 2-methyl-1,4-naphthoquinol + NAD(P)+
-
 ?
1.6.5.2 2-methyl-3-phytyl-1,4-naphthoquinone + NAD(P)H trivial name vitamin K1 Rattus norvegicus 2-methyl-3-phytyl-1,4-naphthohydroquinone + NAD(P)+
-
 ?
1.6.5.2 NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol
-
 Rattus norvegicus NAD(P)+ + reduced 2,6-dichlorophenolindophenol
-
 ?
1.6.5.2 oxidized 2,6-dichlorophenolindophenol + NADH + H+
-
 Rattus norvegicus reduced 2,6-dichlorophenolindophenol + NAD+
-
 r
1.6.5.2 quinone + NAD(P)H protection of cells against damage by reactive oxygen species generated during oxidative cycling of quinones and semiquinone radicals Rattus norvegicus hydroquinone + NAD(P)+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.2 FAD required Rattus norvegicus
1.6.5.2 NADH
-
 Rattus norvegicus
1.6.5.2 NADPH
-
 Rattus norvegicus