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Literature summary extracted from

  • Trepanier, L.A.; Miller, J.L.
    NADH-dependent reduction of sulphamethoxazole hydroxylamine in dog and human liver microsomes (2000), Xenobiotica, 30, 1111-1121.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.7.1.10 additional information not inhibited by a nitrogen atmosphere; not inhibited by azide, CO, dextromethorphan or erythromycin Canis lupus familiaris
1.7.1.10 additional information not inhibited by azide, CO, dextromethorphan or erythromycin Homo sapiens
1.7.1.10 N-Methylhydroxylamine
-
Canis lupus familiaris
1.7.1.10 N-Methylhydroxylamine
-
Homo sapiens
1.7.1.10 p-hydroxymercuribenzoate
-
Canis lupus familiaris
1.7.1.10 p-hydroxymercuribenzoate
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.7.1.10 microsome
-
Homo sapiens
-
-
1.7.1.10 microsome
-
Canis lupus familiaris
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.7.1.10 Canis lupus familiaris
-
2 enzyme forms are present, one may be identical to the multienzyme complex from pig
-
1.7.1.10 Homo sapiens
-
2 enzyme forms are present, one may be identical to the multienzyme complex from pig
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.7.1.10 liver
-
Homo sapiens
-
1.7.1.10 liver
-
Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.7.1.10 sulphamethoxazole hydroxylamine + NADH + H+ activity in liver microsomes, NADH is preferred Homo sapiens sulphamethoxazole + NAD+ + H2O antimicrobial for the treatment of gastrointestinal, urinary and respiratory pathogens ?
1.7.1.10 sulphamethoxazole hydroxylamine + NADH + H+ activity in liver microsomes, NADH is preferred Canis lupus familiaris sulphamethoxazole + NAD+ + H2O antimicrobial for the treatment of gastrointestinal, urinary and respiratory pathogens ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.7.1.10 NADH
-
Homo sapiens
1.7.1.10 NADH
-
Canis lupus familiaris