Literature summary extracted from

Varandani, P.T.; Nafz, M.A.; Chandler, M.L.
Interaction of insulin analogs, glucagon, growth hormone, vasopressin, oxytocin, and scrambled forms of ribonuclease and lysozyme with glutathione-insulin transhydrogenase (thiol: protein-disulfide oxidoreductase): dependence upon conformation (1975), Biochemistry, 14, 2115-2120.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.8.4.2	glucagon	-	Bos taurus
1.8.4.2	Insulin analogs	competitive inhibition of insulin degradation, overview	Bos taurus
1.8.4.2	Oxytoxin	-	Bos taurus
1.8.4.2	Scrambled forms of ribonuclease and lysozyme	inhibition of insulin degradation	Bos taurus
1.8.4.2	Vasopressin	-	Bos taurus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.4.2	Bos taurus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.8.4.2	pancreas	-	Bos taurus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.8.4.2	GSH + insulin	-	Bos taurus	GSSG + reduced insulin chain A and B	-	?
1.8.4.2	GSH + protein disulfide	-	Bos taurus	GSSG + protein-dithiol	-	?

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Release 2023.1 (January 2023)