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Literature summary extracted from
- Inhibition of glutathione-insulin transhydrogenase by metal ions and activation by histidine and other chelating agents (1985), Biochim. Biophys. Acta, 832, 7-13.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.2 | Chelating agents | e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation | Bos taurus |  |
| 1.8.4.2 | EDTA | and other chelating agents activate | Bos taurus | |
| 1.8.4.2 | EDTA | activation negated by metal ions | Bos taurus | |
| 1.8.4.2 | histidine | activates, activation negated by metal ions | Bos taurus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.2 | Ca2+ | - |
Bos taurus | |
| 1.8.4.2 | Hg2+ | - |
Bos taurus | |
| 1.8.4.2 | Se2+ | - |
Bos taurus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.2 | Bos taurus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.4.2 | pancreas | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.2 | GSH + insulin | - |
Bos taurus | GSSG + reduced insulin chain A and B | - |
? | |
| 1.8.4.2 | GSH + protein disulfide | - |
Bos taurus | GSSG + protein-dithiol | - |
? | |
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Release 2023.1 (January 2023)
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