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Literature summary extracted from

  • Lin, Y.L.; Huang, J.L.; Wu, C.S.; Liu, H.G.; Yang, D.Y.
    Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase (2002), Bioorg. Med. Chem. Lett., 12, 1709-1713.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.27 2-(2-chloro-4-methanesulfonylbenzoyl)-1,3-cyclohexanedione potent linear competitive inhibitor Echinochloa crus-galli
1.13.11.27 3-hydroxy-4-phenyl-2-furanone 0.0005 mM, 50% inhibition, may serve as a lead compound for further design of more potent inhibitors Sus scrofa
1.13.11.27 additional information neither epoxybenzoaquinone ester nor 2-hydroxy-3-phenyl-3-butenoic acid is an inhibitor Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.27 0.0043
-
4-hydroxyphenylpyruvate
-
Echinochloa crus-galli

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Echinochloa crus-galli
-
-
-
1.13.11.27 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.27 partial Echinochloa crus-galli

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.27 liver
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
Sus scrofa homogentisate + CO2
-
?
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
Echinochloa crus-galli homogentisate + CO2
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.27 0.0000098
-
2-(2-chloro-4-methanesulfonylbenzoyl)-1,3-cyclohexanedione
-
Echinochloa crus-galli