Literature summary extracted from

Ellis, M.K.; Whitfield, A.C.; Gowans, L.A.; Auton, T.R.; Provan, W.M.; Lock, E.A.; Smith, L.L.
Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione (1995), Toxicol. Appl. Pharmacol., 133, 12-19.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.13.11.27	2-(2-chloro-4-methanesulfonylbenzoyl)-1,3-cyclohexanedione	rapid inactivation of the enzyme by the formation of an enzyme-inhibitor complex that dissociates with recovery of enzyme activity	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.27	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.13.11.27	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.13.11.27	4-hydroxyphenylpyruvate + O2	-	Rattus norvegicus	homogentisate + CO2	-	?

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Release 2023.1 (January 2023)