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Literature summary extracted from

  • Govindaraj, S.; Eisenstein, E.; Jones, L.H.; Sanders-Loehr, J.; Chistoserdov, A.Y.; Davidson, V.L.; Edwards, S.L.
    Aromatic amine dehydrogenase, a second tryptophan tryptophylquinone enzyme (1994), J. Bacteriol., 176, 2922-2929.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
1.4.9.2 stable against guanidine hydrochloride up to 2 M Alcaligenes faecalis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.9.2 aminoguanidine
-
 Alcaligenes faecalis
1.4.9.2 hydrazine
-
 Alcaligenes faecalis
1.4.9.2 hydroxylamine
-
 Alcaligenes faecalis
1.4.9.2 Iproniazid
-
 Alcaligenes faecalis
1.4.9.2 isoniazid
-
 Alcaligenes faecalis
1.4.9.2 phenylhydrazine
-
 Alcaligenes faecalis
1.4.9.2 Semicarbazide
-
 Alcaligenes faecalis
1.4.9.2 tyramine substrate inhibition Alcaligenes faecalis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.9.2 0.0054
-
 tyramine
-
 Alcaligenes faecalis
1.4.9.2 0.25
-
 phenazine methosulfate
-
 Alcaligenes faecalis
1.4.9.2 0.45
-
 phenazine ethosulfate
-
 Alcaligenes faecalis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.9.2 18000
-
 alpha2beta2, 2 * 39000 + 2 * 18000, SDS-PAGE Alcaligenes faecalis
1.4.9.2 39000
-
 alpha2beta2, 2 * 39000 + 2 * 18000, SDS-PAGE Alcaligenes faecalis
1.4.9.2 108900
-
 sedimentation equilibrium Alcaligenes faecalis
1.4.9.2 114000
-
 estimated from subunit molecular weights Alcaligenes faecalis

Organism

EC Number Organism UniProt Comment Textmining
1.4.9.2 Alcaligenes faecalis
-
-
-
1.4.9.2 Alcaligenes faecalis IFO 14479
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.9.2
-
 Alcaligenes faecalis

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.9.2 0.39
-
 cell extract from cells grown in beta-phenylethylamine Alcaligenes faecalis
1.4.9.2 14.3
-
 after purification Alcaligenes faecalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.9.2 phenazine ethosulfate + H2O + 2,6-dichlorophenol indophenol
-
 Alcaligenes faecalis ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
 ?
1.4.9.2 phenazine ethosulfate + H2O + 2,6-dichlorophenol indophenol
-
 Alcaligenes faecalis IFO 14479 ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
 ?
1.4.9.2 phenazine methosulfate + H2O + 2,6-dichlorophenol indophenol
-
 Alcaligenes faecalis ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
 ?
1.4.9.2 phenazine methosulfate + H2O + 2,6-dichlorophenol indophenol
-
 Alcaligenes faecalis IFO 14479 ? + NH3 + reduced 2,6-dichlorophenol indophenol
-
 ?
1.4.9.2 tyramine + acceptor + H2O electron acceptor: phenazine methosulfate or phenazine ethosulfate Alcaligenes faecalis 4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
 ?
1.4.9.2 tyramine + acceptor + H2O electron acceptor: phenazine methosulfate or phenazine ethosulfate Alcaligenes faecalis IFO 14479 4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.9.2 tetramer alpha2beta2, 2 * 39000 + 2 * 18000, SDS-PAGE Alcaligenes faecalis

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.4.9.2 20 60 full activity after incubation for 20 min Alcaligenes faecalis

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.9.2 tryptophan tryptophylquinone
-
 Alcaligenes faecalis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.9.2 0.0084
-
 isoniazid
-
 Alcaligenes faecalis
1.4.9.2 0.186
-
 Iproniazid
-
 Alcaligenes faecalis
1.4.9.2 1.08
-
 tyramine substrate inhibition Alcaligenes faecalis