EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.18 | 1,10-phenanthroline | weak | Bos taurus | |
1.14.14.18 | 1,10-phenanthroline | weak | Gallus gallus | |
1.14.14.18 | 1,10-phenanthroline | weak | Homo sapiens | |
1.14.14.18 | 1,10-phenanthroline | weak | Oryctolagus cuniculus | |
1.14.14.18 | 1,10-phenanthroline | weak | Rattus norvegicus | |
1.14.14.18 | 1,10-phenanthroline | weak | Sus scrofa | |
1.14.14.18 | 2,2'-dipyridyl | weak | Bos taurus | |
1.14.14.18 | 2,2'-dipyridyl | weak | Gallus gallus | |
1.14.14.18 | 2,2'-dipyridyl | weak | Homo sapiens | |
1.14.14.18 | 2,2'-dipyridyl | weak | Oryctolagus cuniculus | |
1.14.14.18 | 2,2'-dipyridyl | weak | Rattus norvegicus | |
1.14.14.18 | 2,2'-dipyridyl | weak | Sus scrofa | |
1.14.14.18 | 4-hydroxymercuribenzoate | - |
Bos taurus | |
1.14.14.18 | 4-hydroxymercuribenzoate | - |
Gallus gallus | |
1.14.14.18 | 4-hydroxymercuribenzoate | - |
Homo sapiens | |
1.14.14.18 | 4-hydroxymercuribenzoate | - |
Oryctolagus cuniculus | |
1.14.14.18 | 4-hydroxymercuribenzoate | - |
Rattus norvegicus | |
1.14.14.18 | 4-hydroxymercuribenzoate | - |
Sus scrofa | |
1.14.14.18 | CO | strong inhibition | Bos taurus | |
1.14.14.18 | CO | strong inhibition | Gallus gallus | |
1.14.14.18 | CO | strong inhibition | Homo sapiens | |
1.14.14.18 | CO | strong inhibition | Oryctolagus cuniculus | |
1.14.14.18 | CO | strong inhibition | Rattus norvegicus | |
1.14.14.18 | CO | strong inhibition | Sus scrofa | |
1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Bos taurus | |
1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Gallus gallus | |
1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Homo sapiens | |
1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Oryctolagus cuniculus | |
1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Rattus norvegicus | |
1.14.14.18 | Co2+ | 0.4 mM, significant inhibition | Sus scrofa | |
1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Bos taurus | |
1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Gallus gallus | |
1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Homo sapiens | |
1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Oryctolagus cuniculus | |
1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Rattus norvegicus | |
1.14.14.18 | Cu2+ | 0.2 mM, significant inhibition | Sus scrofa | |
1.14.14.18 | cysteine | - |
Bos taurus | |
1.14.14.18 | cysteine | - |
Gallus gallus | |
1.14.14.18 | cysteine | - |
Homo sapiens | |
1.14.14.18 | cysteine | - |
Oryctolagus cuniculus | |
1.14.14.18 | cysteine | - |
Rattus norvegicus | |
1.14.14.18 | cysteine | - |
Sus scrofa | |
1.14.14.18 | EDTA | weak | Bos taurus | |
1.14.14.18 | EDTA | weak | Gallus gallus | |
1.14.14.18 | EDTA | weak | Homo sapiens | |
1.14.14.18 | EDTA | weak | Oryctolagus cuniculus | |
1.14.14.18 | EDTA | weak | Rattus norvegicus | |
1.14.14.18 | EDTA | weak | Sus scrofa | |
1.14.14.18 | KCN | strong inhibition | Bos taurus | |
1.14.14.18 | KCN | strong inhibition | Gallus gallus | |
1.14.14.18 | KCN | strong inhibition | Homo sapiens | |
1.14.14.18 | KCN | strong inhibition | Oryctolagus cuniculus | |
1.14.14.18 | KCN | strong inhibition | Rattus norvegicus | |
1.14.14.18 | KCN | strong inhibition | Sus scrofa | |
1.14.14.18 | NaN3 | strong inhibition | Bos taurus | |
1.14.14.18 | NaN3 | strong inhibition | Gallus gallus | |
1.14.14.18 | NaN3 | strong inhibition | Homo sapiens | |
1.14.14.18 | NaN3 | strong inhibition | Oryctolagus cuniculus | |
1.14.14.18 | NaN3 | strong inhibition | Rattus norvegicus | |
1.14.14.18 | NaN3 | strong inhibition | Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.14.18 | 0.005 | - |
protoheme IX | enzyme from spleen and liver | Rattus norvegicus | |
1.14.14.18 | 0.0164 | - |
protoheme IX | enzyme from spleen | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.14.18 | microsome | - |
Gallus gallus | - |
- |
1.14.14.18 | microsome | - |
Homo sapiens | - |
- |
1.14.14.18 | microsome | - |
Rattus norvegicus | - |
- |
1.14.14.18 | microsome | - |
Sus scrofa | - |
- |
1.14.14.18 | microsome | - |
Bos taurus | - |
- |
1.14.14.18 | microsome | - |
Oryctolagus cuniculus | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.14.14.18 | 200000 | - |
gel filtration | Rattus norvegicus |
1.14.14.18 | 200000 | - |
gel filtration | Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Gallus gallus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Homo sapiens | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Rattus norvegicus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Sus scrofa | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Bos taurus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | Oryctolagus cuniculus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.18 | Bos taurus | - |
- |
- |
1.14.14.18 | Gallus gallus | - |
- |
- |
1.14.14.18 | Homo sapiens | - |
- |
- |
1.14.14.18 | Oryctolagus cuniculus | - |
- |
- |
1.14.14.18 | Rattus norvegicus | - |
- |
- |
1.14.14.18 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.18 | brain | - |
Gallus gallus | - |
1.14.14.18 | brain | - |
Homo sapiens | - |
1.14.14.18 | brain | - |
Rattus norvegicus | - |
1.14.14.18 | brain | - |
Sus scrofa | - |
1.14.14.18 | brain | - |
Bos taurus | - |
1.14.14.18 | brain | - |
Oryctolagus cuniculus | - |
1.14.14.18 | heart | - |
Gallus gallus | - |
1.14.14.18 | heart | - |
Homo sapiens | - |
1.14.14.18 | heart | - |
Rattus norvegicus | - |
1.14.14.18 | heart | - |
Sus scrofa | - |
1.14.14.18 | heart | - |
Bos taurus | - |
1.14.14.18 | heart | - |
Oryctolagus cuniculus | - |
1.14.14.18 | kidney | - |
Gallus gallus | - |
1.14.14.18 | kidney | - |
Homo sapiens | - |
1.14.14.18 | kidney | - |
Rattus norvegicus | - |
1.14.14.18 | kidney | - |
Sus scrofa | - |
1.14.14.18 | kidney | - |
Bos taurus | - |
1.14.14.18 | kidney | - |
Oryctolagus cuniculus | - |
1.14.14.18 | liver | - |
Gallus gallus | - |
1.14.14.18 | liver | - |
Homo sapiens | - |
1.14.14.18 | liver | - |
Rattus norvegicus | - |
1.14.14.18 | liver | - |
Sus scrofa | - |
1.14.14.18 | liver | - |
Bos taurus | - |
1.14.14.18 | liver | - |
Oryctolagus cuniculus | - |
1.14.14.18 | lung | - |
Gallus gallus | - |
1.14.14.18 | lung | - |
Homo sapiens | - |
1.14.14.18 | lung | - |
Rattus norvegicus | - |
1.14.14.18 | lung | - |
Sus scrofa | - |
1.14.14.18 | lung | - |
Bos taurus | - |
1.14.14.18 | lung | - |
Oryctolagus cuniculus | - |
1.14.14.18 | macrophage | peritoneal, alveolar | Gallus gallus | - |
1.14.14.18 | macrophage | peritoneal, alveolar | Homo sapiens | - |
1.14.14.18 | macrophage | peritoneal, alveolar | Rattus norvegicus | - |
1.14.14.18 | macrophage | peritoneal, alveolar | Sus scrofa | - |
1.14.14.18 | macrophage | peritoneal, alveolar | Bos taurus | - |
1.14.14.18 | macrophage | peritoneal, alveolar | Oryctolagus cuniculus | - |
1.14.14.18 | marrow | - |
Gallus gallus | - |
1.14.14.18 | marrow | - |
Homo sapiens | - |
1.14.14.18 | marrow | - |
Rattus norvegicus | - |
1.14.14.18 | marrow | - |
Sus scrofa | - |
1.14.14.18 | marrow | - |
Bos taurus | - |
1.14.14.18 | marrow | - |
Oryctolagus cuniculus | - |
1.14.14.18 | small intestine mucosa | - |
Gallus gallus | - |
1.14.14.18 | small intestine mucosa | - |
Homo sapiens | - |
1.14.14.18 | small intestine mucosa | - |
Rattus norvegicus | - |
1.14.14.18 | small intestine mucosa | - |
Sus scrofa | - |
1.14.14.18 | small intestine mucosa | - |
Bos taurus | - |
1.14.14.18 | small intestine mucosa | - |
Oryctolagus cuniculus | - |
1.14.14.18 | spleen | - |
Gallus gallus | - |
1.14.14.18 | spleen | - |
Homo sapiens | - |
1.14.14.18 | spleen | - |
Rattus norvegicus | - |
1.14.14.18 | spleen | - |
Sus scrofa | - |
1.14.14.18 | spleen | - |
Bos taurus | - |
1.14.14.18 | spleen | - |
Oryctolagus cuniculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.14.14.18 | additional information | - |
assay procedure | Gallus gallus |
1.14.14.18 | additional information | - |
assay procedure | Homo sapiens |
1.14.14.18 | additional information | - |
assay procedure | Rattus norvegicus |
1.14.14.18 | additional information | - |
assay procedure | Sus scrofa |
1.14.14.18 | additional information | - |
assay procedure | Bos taurus |
1.14.14.18 | additional information | - |
assay procedure | Oryctolagus cuniculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Gallus gallus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Homo sapiens | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Rattus norvegicus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Sus scrofa | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Bos taurus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Oryctolagus cuniculus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Gallus gallus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Homo sapiens | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Sus scrofa | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Bos taurus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Oryctolagus cuniculus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Gallus gallus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Homo sapiens | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Sus scrofa | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Bos taurus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Oryctolagus cuniculus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
1.14.14.18 | methemoglobin + electron donor + O2 | - |
Gallus gallus | ? | - |
? | |
1.14.14.18 | methemoglobin + electron donor + O2 | - |
Homo sapiens | ? | - |
? | |
1.14.14.18 | methemoglobin + electron donor + O2 | - |
Rattus norvegicus | ? | - |
? | |
1.14.14.18 | methemoglobin + electron donor + O2 | - |
Sus scrofa | ? | - |
? | |
1.14.14.18 | methemoglobin + electron donor + O2 | - |
Bos taurus | ? | - |
? | |
1.14.14.18 | methemoglobin + electron donor + O2 | - |
Oryctolagus cuniculus | ? | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.14.18 | 37 | - |
assay at | Gallus gallus |
1.14.14.18 | 37 | - |
assay at | Homo sapiens |
1.14.14.18 | 37 | - |
assay at | Rattus norvegicus |
1.14.14.18 | 37 | - |
assay at | Sus scrofa |
1.14.14.18 | 37 | - |
assay at | Bos taurus |
1.14.14.18 | 37 | - |
assay at | Oryctolagus cuniculus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.14.18 | - |
4 | several hours | Gallus gallus |
1.14.14.18 | - |
4 | several hours | Homo sapiens |
1.14.14.18 | - |
4 | several hours | Rattus norvegicus |
1.14.14.18 | - |
4 | several hours | Sus scrofa |
1.14.14.18 | - |
4 | several hours | Bos taurus |
1.14.14.18 | - |
4 | several hours | Oryctolagus cuniculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.14.14.18 | 7.4 | - |
- |
Rattus norvegicus |