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Literature summary extracted from

  • Csonga, R.; Ettmayer, P.; Auer, M.; Eckerskorn, C.; Eder, J.; Klier, H.
    Evaluation of the metal ion requirement of the human deoxyhypusine hydroxylase from HeLa cells using a novel enzyme assay (1996), FEBS Lett., 380, 209-214.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.29 2,2'-dipyridyl IC50 0.029 mM Homo sapiens
1.14.99.29 4,6-diphenyl-1-hydroxy-pyridine-2-one IC50 0.0007 mM Homo sapiens
1.14.99.29 ciclopirox IC50 0.0006 mM Homo sapiens
1.14.99.29 Co(C2H3O2)2 above 0.01 mM Homo sapiens
1.14.99.29 CuCl2 above 0.01 mM Homo sapiens
1.14.99.29 EDTA IC50 0.0003 mM Homo sapiens
1.14.99.29 metipirox IC50 0.0028 mM Homo sapiens
1.14.99.29 mimosine IC50 0.0033 mM Homo sapiens
1.14.99.29 Mn(C2H3O2)2 above 0.001 mM Homo sapiens
1.14.99.29 additional information partial reconstitution of chelator inhibited activity with CuCl2 or Zn(C2H3O2)2 Homo sapiens
1.14.99.29 Ni(C2H3O2)2 above 0.001 mM Homo sapiens
1.14.99.29 Zn(C2H3O2)2 above 0.01 mM Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.99.29 Fe2+ 1.5-fold activation at 0.001 mM Homo sapiens
1.14.99.29 Fe3+ 1.5-fold activation at 0.001 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.29 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.29 HeLa-S3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.29 N'-(4-aminobutyl)lysine + electron donor + O2 i.e. deoxyhypusine Homo sapiens N'-(4-amino-2-hydroxybutyl)lysine + oxidized electron donor + H2O i.e. hypusine ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.99.29 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.99.29 7.5
-
assay in 50 mM sodium phosphate buffer Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.99.29 0.0003
-
IC50 0.0003 mM Homo sapiens EDTA
1.14.99.29 0.0006
-
IC50 0.0006 mM Homo sapiens ciclopirox
1.14.99.29 0.0007
-
IC50 0.0007 mM Homo sapiens 4,6-diphenyl-1-hydroxy-pyridine-2-one
1.14.99.29 0.0028
-
IC50 0.0028 mM Homo sapiens metipirox
1.14.99.29 0.0033
-
IC50 0.0033 mM Homo sapiens mimosine
1.14.99.29 0.029
-
IC50 0.029 mM Homo sapiens 2,2'-dipyridyl