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Literature summary extracted from
- Vitamin K epoxidase: properties and relationship to prothrombin synthesis (1977), Biochemistry, 16, 3856-3863.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.14.99.20 | preincubation for 15 min at 37°C results in an almost complete inhibition of the epoxidation | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.20 | 2-chloro-3-phytyl-1,4-naphthoquinone | - |
Rattus norvegicus |  |
| 1.14.99.20 | Tetrachloro-4-pyridinol | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.99.20 | microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.20 | phylloquinone + electron donor + O2 | Rattus norvegicus | - |
2,3-epoxyphylloquinone + oxidized electron + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.20 | Rattus norvegicus | - |
Holtzman strain, male rats | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.99.20 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.20 | additional information | NADH or NADPH, if reduced pyridine nucleotides are provided, no cytosolic component is required | Rattus norvegicus | ? | - |
? | |
| 1.14.99.20 | phylloquinone + electron donor + O2 | - |
Rattus norvegicus | 2,3-epoxyphylloquinone + oxidized electron donor + H2O | - |
? | |
| 1.14.99.20 | phylloquinone + electron donor + O2 | - |
Rattus norvegicus | 2,3-epoxyphylloquinone + oxidized electron + H2O | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.20 | 27 | - |
enzyme assay | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.20 | NADH | - |
Rattus norvegicus | |
| 1.14.99.20 | NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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