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Literature summary extracted from

  • D'Andrea, S.; Guillou, H.; Jan, S.; Catheline, D.; Thibault, J.N.; Bouriel, M.; Rioux, V.; Legrand, P.
    The same rat DELTA6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis (2002), Biochem. J., 364, 49-55.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.3 DELTA6-desaturase gene identified in human chromosome 11 Homo sapiens
1.14.19.3 plasmid coding for rat delta6-desaturase constructed using pCMV for expression in mammalian cells, rat delta6-desaturase sequence, GenBank accession number AB02 1980 PCR amplified, expressed by transiently transforming COS-7 cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.3 microsome
-
 Homo sapiens
-
-
1.14.19.3 microsome
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.19.3 45000
-
 recombinant DELTA6-desaturase expressed in COS-7 cells, analysed by Western blot Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.3 linoleic acid + AH2 + O2 Homo sapiens
-
 gamma-linolenic acid + A + H2O
-
 ?
1.14.19.3 linoleic acid + AH2 + O2 Rattus norvegicus
-
 gamma-linolenic acid + A + H2O
-
 ?
1.14.19.3 linoleic acid + AH2 + O2 Rattus norvegicus Sprague-Dawley
-
 gamma-linolenic acid + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.3 Homo sapiens
-
 human
-
1.14.19.3 Rattus norvegicus
-
-
-
1.14.19.3 Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.3 brain
-
 Homo sapiens
-
1.14.19.3 brain
-
 Rattus norvegicus
-
1.14.19.3 liver
-
 Homo sapiens
-
1.14.19.3 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.3 24-carbon fatty acid + AH2 + O2
-
 Rattus norvegicus ? + A + H2O
-
 ?
1.14.19.3 24-carbon fatty acid + AH2 + O2
-
 Rattus norvegicus Sprague-Dawley ? + A + H2O
-
 ?
1.14.19.3 alpha-linolenic acid + AH2 + O2
-
 Homo sapiens stearidonic acid + A + 2 H2O
-
 ?
1.14.19.3 alpha-linolenic acid + AH2 + O2
-
 Rattus norvegicus stearidonic acid + A + 2 H2O
-
 ?
1.14.19.3 alpha-linolenic acid + AH2 + O2
-
 Rattus norvegicus Sprague-Dawley stearidonic acid + A + 2 H2O
-
 ?
1.14.19.3 linoleic acid + AH2 + O2
-
 Homo sapiens gamma-linolenic acid + A + H2O
-
 ?
1.14.19.3 linoleic acid + AH2 + O2
-
 Rattus norvegicus gamma-linolenic acid + A + H2O
-
 ?
1.14.19.3 linoleic acid + AH2 + O2
-
 Rattus norvegicus Sprague-Dawley gamma-linolenic acid + A + H2O
-
 ?
1.14.19.3 octadeca-9,12-dienoic acid + AH2 + O2
-
 Homo sapiens gamma-linolenic acid + A + H2O
-
 ?
1.14.19.3 octadeca-9,12-dienoic acid + AH2 + O2
-
 Rattus norvegicus gamma-linolenic acid + A + H2O
-
 ?
1.14.19.3 octadeca-9,12-dienoic acid + AH2 + O2
-
 Rattus norvegicus Sprague-Dawley gamma-linolenic acid + A + H2O
-
 ?
1.14.19.3 octadecanoate + AH2 + O2
-
 Rattus norvegicus ? + A + H2O
-
 ?
1.14.19.3 octadecanoate + AH2 + O2
-
 Rattus norvegicus Sprague-Dawley ? + A + H2O
-
 ?