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Literature summary extracted from

  • Taniguchi, S.; Hoshita, N.; Okuda, K.
    Enzymatic characteristics of CO-sensitive 26-hydroxylase system for 5beta-cholestane-3alpha,7alpha 12alpha-triol in rat-liver mitochondria and its intramitochondrial localization (1973), Eur. J. Biochem., 40, 607-617.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.15 CO at a CO:O2 ratio of 0.75 hydroxylation reaction is undetectable Rattus norvegicus
1.14.15.15 dicoumarol 10% inhibition at 0.05 mM Rattus norvegicus
1.14.15.15 p-chloromercuriphenyl sulfonate 80% inhibition at 0.1 mM Rattus norvegicus
1.14.15.15 Phenyl isocyanide 70% inhibition at 0.1 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.15.15 0.01 0.02 O2
-
Rattus norvegicus
1.14.15.15 0.06
-
5beta-cholestane-3alpha,7alpha,12alpha-triol
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.15 mitochondrial membrane inner membrane-matrix Rattus norvegicus 31966
-
1.14.15.15 additional information only the mitochondrial hydroxylase system is specific for C-26 position, the microsomal system is unspecific for C-26 position but rather more active for other adjacent positions Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2 Rattus norvegicus
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.15 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.15 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2 isocitrate can act as electron donor Rattus norvegicus 5beta-cholestane-3alpha,7alpha,12alpha,27-tetrol + oxidized adrenodoxin + H2O
-
?
1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2 mitochondrial enzyme is specific for 26-hydroxylation whereas the reaction with the microsomal enzyme hydroxylates at position 23, 24, 25 and 26 Rattus norvegicus 5beta-cholestane-3alpha,7alpha,12alpha,27-tetrol + oxidized adrenodoxin + H2O
-
?
1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2
-
Rattus norvegicus ?
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.15 cytochrome P450 possible function of a cytochrome-P450-like entity in the intramitochondrial 26-hydroxylase system Rattus norvegicus
1.14.15.15 NADPH
-
Rattus norvegicus