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Literature summary extracted from

  • Holme, E.; Lindstedt, S.; Nordin, I.
    Uncoupling in the gamma-butyrobetaine hydroxylase reaction by D- and L-carnitine (1982), Biochem. Biophys. Res. Commun., 107, 518-524.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.1 D-carnitine uncoupling agent Pseudomonas sp.
1.14.11.1 DL-carnitine uncouples the decarboxylation from the hydroxylation, mammalian enzyme Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.11.1 0.25
-
 2-oxoglutarate
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.1 cytoplasm
-
 Homo sapiens 5737
-
1.14.11.1 cytoplasm
-
 Pseudomonas sp. 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.1 Fe2+ requirement Homo sapiens
1.14.11.1 Fe2+ requirement Pseudomonas sp.

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.1 Homo sapiens
-
-
-
1.14.11.1 Pseudomonas sp.
-
 AK1
-
1.14.11.1 Pseudomonas sp. AK1
-
 AK1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.1 kidney
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.11.1 0.162
-
 human kidney Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.1 4-trimethylammoniobutanoate + 2-oxoglutarate + O2
-
 Homo sapiens 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2
-
 ?
1.14.11.1 4-trimethylammoniobutanoate + 2-oxoglutarate + O2
-
 Pseudomonas sp. 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2
-
 ?
1.14.11.1 4-trimethylammoniobutanoate + 2-oxoglutarate + O2
-
 Pseudomonas sp. AK1 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2
-
 ?
1.14.11.1 additional information L-carnithine is an uncoupler Homo sapiens ?
-
 ?
1.14.11.1 additional information L-carnithine is an uncoupler Pseudomonas sp. ?
-
 ?
1.14.11.1 additional information L-carnithine is an uncoupler Pseudomonas sp. AK1 ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.1 37
-
 assay at Homo sapiens
1.14.11.1 37
-
 assay at Pseudomonas sp.

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.14.11.1 50
-
 12 min half-life Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.1 ascorbate
-
 Homo sapiens
1.14.11.1 ascorbate
-
 Pseudomonas sp.