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Literature summary extracted from

  • Petrov, R.R.; Utkin, I.B.; Popov, V.O.
    Effect of redox potential on the activation of the NAD-dependent hydrogenase from Alcaligenes eutrophus Z1 (1989), Arch. Biochem. Biophys., 268, 287-297.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.12.1.2 additional information at a redox potential of approx. -100 mV the inactive form of the enzyme is transformed into an active one Cupriavidus necator

General Stability

EC Number General Stability Organism
1.12.1.2 oxidized inactive form of the enzyme is the most stable against thermodenaturation, proteolysis, and inactivation in urea Cupriavidus necator

Organism

EC Number Organism UniProt Comment Textmining
1.12.1.2 Cupriavidus necator
-
-
-
1.12.1.2 Cupriavidus necator
-
 formerly Alcaligenes eutrophus
-
1.12.1.2 Cupriavidus necator Z1
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
1.12.1.2 redox-dependent inactivation and activation, proposed inactivation mechanism Cupriavidus necator

Reaction

EC Number Reaction Comment Organism Reaction ID
1.12.1.2 H2 + NAD+ = H+ + NADH catalytic activity may be regulated by the reduction of a regulatory center followed by a series of structural changes Cupriavidus necator
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.12.1.2 H2 + NAD+
-
 Cupriavidus necator H+ + NADH
-
 ?
1.12.1.2 H2 + NAD+
-
 Cupriavidus necator Z1 H+ + NADH
-
 ?