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Literature summary extracted from

  • Theilgaard, H.B.A.; Kristiansen, K.N.; Henriksen, C.M.; Nielsen, J.
    Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum (1997), Biochem. J., 327, 185-191.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.26 bis-delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine
-
Penicillium chrysogenum
6.3.2.26 dithiothreitol
-
Penicillium chrysogenum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.2.26 0.045
-
L-aminoadipate
-
Penicillium chrysogenum
6.3.2.26 0.08
-
L-cysteine
-
Penicillium chrysogenum
6.3.2.26 0.08
-
L-valine
-
Penicillium chrysogenum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.26 Mg2+ optimal concentration: 20 mM Penicillium chrysogenum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.2.26 470000
-
gradient PAGE Penicillium chrysogenum

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.26 Penicillium chrysogenum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.26
-
Penicillium chrysogenum

Storage Stability

EC Number Storage Stability Organism
6.3.2.26 -80°C, several months Penicillium chrysogenum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.26 L-2-aminoadipate + L-cysteine + L-valine + ATP
-
Penicillium chrysogenum N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
-
?

Subunits

EC Number Subunits Comment Organism
6.3.2.26 monomer 1 * 470000, SDS-PAGE Penicillium chrysogenum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.26 7.8
-
in MOPS buffer Penicillium chrysogenum
6.3.2.26 8.4
-
in Tris buffer Penicillium chrysogenum

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.26 ATP optimal concentration: 5 mM Penicillium chrysogenum