Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Paulson, S.K.; DeLuca, H.F.
    Subcellular location and properties of rat renal 25-hydroxyvitamin D3-1 alpha-hydroxylase (1985), J. Biol. Chem., 260, 11488-11492.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.15.18 succinate supports 1alpha-hydroxylation as electron donor Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.18 antimycin A inhibition occurs with succinate reaction support, no inhibition together with malate Rattus norvegicus
1.14.15.18 dinitrophenol
-
 Rattus norvegicus
1.14.15.18 diphenyl-p-phenylenediamine no inhibition Rattus norvegicus
1.14.15.18 Metyrapone
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.18 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.18 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.18 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.18 calcidiol + NADPH + O2 highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol Rattus norvegicus calcitriol + NADP+ + H2O calcitriol is identical with 1,25-dihydroxycholecalciferol ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.18 NADPH
-
 Rattus norvegicus