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Literature summary extracted from

  • Stover, P.; Schirch, V.
    5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase (1991), J. Biol. Chem., 266, 1543-1550.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.1 5-formyltetrahydrofolate monoglutamate
-
 Escherichia coli
2.1.2.1 5-formyltetrahydrofolate monoglutamate
-
 Oryctolagus cuniculus
2.1.2.1 5-methyltetrahydrofolate monoglutamate
-
 Escherichia coli
2.1.2.1 5-methyltetrahydrofolate monoglutamate
-
 Oryctolagus cuniculus
2.1.2.1 5-Methyltetrahydrofolate triglutamate
-
 Escherichia coli
2.1.2.1 5-Methyltetrahydrofolate triglutamate
-
 Oryctolagus cuniculus
2.1.2.1 additional information
-
 Escherichia coli
2.1.2.1 additional information inhibition kinetics Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.2.1 cytoplasm
-
 Escherichia coli 5737
-
2.1.2.1 cytoplasm
-
 Oryctolagus cuniculus 5737
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Escherichia coli
-
-
-
2.1.2.1 Oryctolagus cuniculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Escherichia coli
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Oryctolagus cuniculus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate
-
 Escherichia coli glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Oryctolagus cuniculus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 pyridoxal 5'-phosphate
-
 Escherichia coli
2.1.2.1 pyridoxal 5'-phosphate
-
 Oryctolagus cuniculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.2.1 additional information
-
 additional information
-
 Oryctolagus cuniculus