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Literature summary extracted from

  • Schirch, L.
    Serine hydroxymethyltransferase (1982), Adv. Enzymol. Relat. Areas Mol. Biol., 53, 83-112.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.1 D-alanine
-
 Bos taurus
2.1.2.1 D-alanine
-
 Cricetulus griseus
2.1.2.1 D-alanine
-
 Oryctolagus cuniculus
2.1.2.1 D-alanine
-
 Ovis aries
2.1.2.1 D-beta-fluoroalanine
-
 Bos taurus
2.1.2.1 D-beta-fluoroalanine
-
 Cricetulus griseus
2.1.2.1 D-beta-fluoroalanine
-
 Oryctolagus cuniculus
2.1.2.1 D-beta-fluoroalanine
-
 Ovis aries
2.1.2.1 D-cycloserine
-
 Bos taurus
2.1.2.1 D-cycloserine
-
 Cricetulus griseus
2.1.2.1 D-cycloserine
-
 Oryctolagus cuniculus
2.1.2.1 D-cycloserine
-
 Ovis aries
2.1.2.1 L-methionine
-
 Saccharomyces cerevisiae
2.1.2.1 methyl methanethiosulfonate
-
 Bos taurus
2.1.2.1 methyl methanethiosulfonate
-
 Cricetulus griseus
2.1.2.1 methyl methanethiosulfonate
-
 Oryctolagus cuniculus
2.1.2.1 methyl methanethiosulfonate
-
 Ovis aries
2.1.2.1 S-adenosyl-L-methionine
-
 Saccharomyces cerevisiae
2.1.2.1 tetrahydrofolate derivatives
-
 Bos taurus
2.1.2.1 tetrahydrofolate derivatives
-
 Cricetulus griseus
2.1.2.1 tetrahydrofolate derivatives
-
 Oryctolagus cuniculus
2.1.2.1 tetrahydrofolate derivatives
-
 Ovis aries

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.1 additional information
-
 additional information
-
 Saccharomyces cerevisiae
2.1.2.1 additional information
-
 additional information pH-dependence of kinetic parameters Cricetulus griseus
2.1.2.1 additional information
-
 additional information pH-dependence of kinetic parameters Bos taurus
2.1.2.1 additional information
-
 additional information pH-dependence of kinetic parameters Oryctolagus cuniculus
2.1.2.1 additional information
-
 additional information pH-dependence of kinetic parameters Ovis aries

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.2.1 cytoplasm
-
 Salmonella enterica subsp. enterica serovar Typhimurium 5737
-
2.1.2.1 cytoplasm
-
 Cricetulus griseus 5737
-
2.1.2.1 cytoplasm
-
 Saccharomyces cerevisiae 5737
-
2.1.2.1 cytoplasm
-
 Bos taurus 5737
-
2.1.2.1 cytoplasm
-
 Oryctolagus cuniculus 5737
-
2.1.2.1 cytoplasm
-
 Neurospora crassa 5737
-
2.1.2.1 cytoplasm
-
 Ovis aries 5737
-
2.1.2.1 mitochondrion
-
 Saccharomyces cerevisiae 5739
-
2.1.2.1 mitochondrion matrix Cricetulus griseus 5739
-
2.1.2.1 mitochondrion matrix Bos taurus 5739
-
2.1.2.1 mitochondrion matrix Oryctolagus cuniculus 5739
-
2.1.2.1 mitochondrion matrix Ovis aries 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate Saccharomyces cerevisiae
-
 glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Salmonella enterica subsp. enterica serovar Typhimurium may play important role in central nervous system glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Cricetulus griseus may play important role in central nervous system glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Bos taurus may play important role in central nervous system glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Oryctolagus cuniculus may play important role in central nervous system glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Neurospora crassa may play important role in central nervous system glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Ovis aries may play important role in central nervous system glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Bos taurus
-
-
-
2.1.2.1 Cricetulus griseus
-
-
-
2.1.2.1 Neurospora crassa
-
-
-
2.1.2.1 Oryctolagus cuniculus
-
-
-
2.1.2.1 Ovis aries
-
-
-
2.1.2.1 Saccharomyces cerevisiae
-
-
-
2.1.2.1 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Salmonella enterica subsp. enterica serovar Typhimurium
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Cricetulus griseus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Bos taurus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Oryctolagus cuniculus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Neurospora crassa
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Ovis aries
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine stereochemistry Salmonella enterica subsp. enterica serovar Typhimurium
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine stereochemistry Cricetulus griseus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine stereochemistry Bos taurus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine stereochemistry Oryctolagus cuniculus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine stereochemistry Neurospora crassa
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine stereochemistry Ovis aries
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.1 ovary
-
 Cricetulus griseus
-

Storage Stability

EC Number Storage Stability Organism
2.1.2.1 frozen, several months at pH 7.3 Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Salmonella enterica subsp. enterica serovar Typhimurium D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Cricetulus griseus D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Saccharomyces cerevisiae D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Bos taurus D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Oryctolagus cuniculus D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Neurospora crassa D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Ovis aries D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Salmonella enterica subsp. enterica serovar Typhimurium glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Cricetulus griseus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Saccharomyces cerevisiae glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Bos taurus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Oryctolagus cuniculus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 r
2.1.2.1 L-serine + tetrahydrofolate
-
 Neurospora crassa glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Ovis aries glycine + 5,10-methylenetetrahydrofolate + H2O
-
 r
2.1.2.1 L-serine + tetrahydrofolate may play important role in central nervous system Salmonella enterica subsp. enterica serovar Typhimurium glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate may play important role in central nervous system Cricetulus griseus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate may play important role in central nervous system Bos taurus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate may play important role in central nervous system Oryctolagus cuniculus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate may play important role in central nervous system Neurospora crassa glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate may play important role in central nervous system Ovis aries glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 additional information
-
 Saccharomyces cerevisiae ?
-
 ?
2.1.2.1 additional information no: L-threonine Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.1.2.1 additional information no: L-threonine Cricetulus griseus ?
-
 ?
2.1.2.1 additional information no: L-threonine Bos taurus ?
-
 ?
2.1.2.1 additional information no: L-threonine Oryctolagus cuniculus ?
-
 ?
2.1.2.1 additional information no: L-threonine Neurospora crassa ?
-
 ?
2.1.2.1 additional information no: L-threonine Ovis aries ?
-
 ?
2.1.2.1 additional information no: D-serine Cricetulus griseus ?
-
 ?
2.1.2.1 additional information no: D-serine Bos taurus ?
-
 ?
2.1.2.1 additional information no: D-serine Oryctolagus cuniculus ?
-
 ?
2.1.2.1 additional information no: D-serine Ovis aries ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Cricetulus griseus ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Bos taurus ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Oryctolagus cuniculus ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Neurospora crassa ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Ovis aries ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.2.1 homotetramer
-
 Cricetulus griseus
2.1.2.1 homotetramer
-
 Saccharomyces cerevisiae
2.1.2.1 homotetramer
-
 Bos taurus
2.1.2.1 homotetramer
-
 Oryctolagus cuniculus
2.1.2.1 homotetramer
-
 Ovis aries

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.1.2.1 30
-
 several h, pH 5.8-8.5, cytosol Oryctolagus cuniculus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.1.2.1 5.8 8.5 stable, rabbit cytosol Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 pyridoxal 5'-phosphate
-
 Saccharomyces cerevisiae
2.1.2.1 pyridoxal 5'-phosphate requirement, 4 mol per mol enzyme Cricetulus griseus
2.1.2.1 pyridoxal 5'-phosphate requirement, 4 mol per mol enzyme Bos taurus
2.1.2.1 pyridoxal 5'-phosphate requirement, 4 mol per mol enzyme Oryctolagus cuniculus
2.1.2.1 pyridoxal 5'-phosphate requirement, 4 mol per mol enzyme Ovis aries
2.1.2.1 pyridoxal 5'-phosphate mechanism, active-site structure Cricetulus griseus
2.1.2.1 pyridoxal 5'-phosphate mechanism, active-site structure Bos taurus
2.1.2.1 pyridoxal 5'-phosphate mechanism, active-site structure Oryctolagus cuniculus
2.1.2.1 pyridoxal 5'-phosphate mechanism, active-site structure Ovis aries
2.1.2.1 tetrahydrofolate requirement with L-serine or L-2-methylserine as substrate Cricetulus griseus
2.1.2.1 tetrahydrofolate requirement with L-serine or L-2-methylserine as substrate Saccharomyces cerevisiae
2.1.2.1 tetrahydrofolate requirement with L-serine or L-2-methylserine as substrate Bos taurus
2.1.2.1 tetrahydrofolate requirement with L-serine or L-2-methylserine as substrate Oryctolagus cuniculus
2.1.2.1 tetrahydrofolate requirement with L-serine or L-2-methylserine as substrate Ovis aries
2.1.2.1 tetrahydrofolate mechanism Cricetulus griseus
2.1.2.1 tetrahydrofolate mechanism Bos taurus
2.1.2.1 tetrahydrofolate mechanism Oryctolagus cuniculus
2.1.2.1 tetrahydrofolate mechanism Ovis aries