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Literature summary extracted from

  • Sakamoto, M.; Masuda, T.; Yanagimoto, Y.; Nakano, Y.; Kitaoka, S.; Tanigawa, Y.
    Purification and characterization of serine hydroxymethyltransferase from mitochondria of Euglena gracilis z (1996), Biosci. Biotechnol. Biochem., 60, 1941-1944.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.1 beta-Alanine
-
 Euglena gracilis
2.1.2.1 glycine
-
 Euglena gracilis
2.1.2.1 L-alanine
-
 Euglena gracilis
2.1.2.1 L-alpha,beta-diaminopropionic acid
-
 Euglena gracilis
2.1.2.1 L-amino acids
-
 Euglena gracilis
2.1.2.1 L-cysteine
-
 Euglena gracilis
2.1.2.1 L-methionine not Euglena gracilis
2.1.2.1 L-serine
-
 Euglena gracilis
2.1.2.1 additional information not: valine, leucine, glutamic acid, 3-hydroxybutyric acid Euglena gracilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.1 0.15 0.9 L-serine
-
 Euglena gracilis
2.1.2.1 65.3
-
 L-serine
-
 Euglena gracilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.2.1 chloroplast
-
 Euglena gracilis 9507
-
2.1.2.1 cytoplasm
-
 Euglena gracilis 5737
-
2.1.2.1 mitochondrion
-
 Euglena gracilis 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.2.1 44000
-
 2 * 44000, SDS-PAGE Euglena gracilis
2.1.2.1 88000
-
 gel filtration Euglena gracilis

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Euglena gracilis
-
-
-
2.1.2.1 Euglena gracilis Z
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.1
-
 Euglena gracilis

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.2.1 additional information
-
-
 Euglena gracilis
2.1.2.1 0.048
-
 reaction of L-serine Euglena gracilis
2.1.2.1 0.15
-
 reaction of L-threonine Euglena gracilis
2.1.2.1 1.388
-
 reaction of L-allothreonine Euglena gracilis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate
-
 Euglena gracilis glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Euglena gracilis Z glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 additional information no: D-serine Euglena gracilis ?
-
 ?
2.1.2.1 additional information no: D-allothreonine Euglena gracilis ?
-
 ?
2.1.2.1 additional information no: D-threonine Euglena gracilis ?
-
 ?
2.1.2.1 additional information no: D-serine Euglena gracilis Z ?
-
 ?
2.1.2.1 additional information no: D-allothreonine Euglena gracilis Z ?
-
 ?
2.1.2.1 additional information no: D-threonine Euglena gracilis Z ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.2.1 dimer 2 * 44000, SDS-PAGE Euglena gracilis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.2.1 6.8
-
-
 Euglena gracilis

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 pyridoxal 5'-phosphate 2 mol per mol enzyme Euglena gracilis
2.1.2.1 tetrahydrofolate requirement with L-serine or L-2-methylserine as substrate Euglena gracilis