Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Straka, J.G.; Kushner, J.P.
    Purification and characterization of bovine hepatic uroporphyrinogen decarboxylase (1983), Biochemistry, 22, 4664-4672.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.37 2,2'-dipyridyl disulfide
-
 Bos taurus
4.1.1.37 5,5'-dithiobis(2-nitrobenzoate)
-
 Bos taurus
4.1.1.37 Al3+
-
 Bos taurus
4.1.1.37 Co2+
-
 Bos taurus
4.1.1.37 Cu2+
-
 Bos taurus
4.1.1.37 Fe2+
-
 Bos taurus
4.1.1.37 iodoacetamide
-
 Bos taurus
4.1.1.37 Pb2+
-
 Bos taurus
4.1.1.37 Zn2+
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.37 0.00042
-
 6-COOH-porphyrinogen I
-
 Bos taurus
4.1.1.37 0.00043
-
 5-COOH-porphyrinogen III
-
 Bos taurus
4.1.1.37 0.00044
-
 7-COOH-porphyrinogen I
-
 Bos taurus
4.1.1.37 0.00064
-
 6-COOH-porphyrinogen III
-
 Bos taurus
4.1.1.37 0.00079
-
 8-COOH-porphyrinogen I
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.37 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.37
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.37 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.37 0.016
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.37 5-COOH-porphyrinogen III
-
 Bos taurus Coproporphyrinogen III + CO2
-
 ?
4.1.1.37 6-COOH-porphyrinogen I
-
 Bos taurus Coproporphyrinogen I + CO2
-
 ?
4.1.1.37 6-COOH-porphyrinogen III
-
 Bos taurus Coproporphyrinogen III + CO2
-
 ?
4.1.1.37 7-COOH-porphyrinogen I
-
 Bos taurus Coproporphyrinogen I + CO2
-
 ?
4.1.1.37 8-COOH-porphyrinogen I
-
 Bos taurus Coproporphyrinogen I + CO2
-
 ?
4.1.1.37 additional information
-
 Bos taurus additional information the pattern of accumulation of intermediate 7-COOH-porphyrinogens, 6-COOH-porphyrinogens and 5-COOH-porphyrinogens and final coproporphyrinogen decarboxylation products is affected by the ratio of substrate concentration of uroporphyrinogen I or II to enzyme concentration. Under physiological conditions, where the uroporphyrinogen to enzyme ratio is low, the substrate is nearly quantitatively decarboxylated, and the major product is coproporphyrinogen ?
4.1.1.37 uroporphyrinogen I
-
 Bos taurus coproporphyrinogen I + 4 CO2
-
 ?
4.1.1.37 Uroporphyrinogen III
-
 Bos taurus Coproporphyrinogen III + 4 CO2
-
 ?