Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Mukerji, S.K.; Pimstone, N.R.
    In vitro studies of the mechanism of inhibition of rat liver uroporphyrinogen decarboxylase activity by ferrous iron under anaerobic conditions (1986), Arch. Biochem. Biophys., 224, 619-629.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.37 5,5'-dithiobis(2-nitrobenzoate)
-
 Rattus norvegicus
4.1.1.37 Fe2+ 0.45 mM Fe(NH4)2, 50% inhibition under anaerobic conditions in the dark. Competitive with uroporphyrinogen I and uroporphyrinogen II as substrates. Preincubation with 5-COOH-porphyrinogen protects Rattus norvegicus
4.1.1.37 Hg2+
-
 Rattus norvegicus
4.1.1.37 Zn2+
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.37 0.0003
-
 6-COOH-porphyrinogen I
-
 Rattus norvegicus
4.1.1.37 0.00133
-
 5-COOH-porphyrinogen I
-
 Rattus norvegicus
4.1.1.37 0.00182
-
 uroporphyrinogen III
-
 Rattus norvegicus
4.1.1.37 0.00285
-
 6-COOH-porphyrinogen I
-
 Rattus norvegicus
4.1.1.37 0.00318
-
 Uroporphyrinogen I
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.37 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.37 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.37 5-COOH-porphyrinogen I
-
 Rattus norvegicus Coproporphyrinogen I + CO2
-
 ?
4.1.1.37 6-COOH-porphyrinogen I
-
 Rattus norvegicus Coproporphyrinogen I + CO2
-
 ?
4.1.1.37 7-COOH-porphyrinogen I
-
 Rattus norvegicus Coproporphyrinogen I + CO2
-
 ?
4.1.1.37 uroporphyrinogen I
-
 Rattus norvegicus coproporphyrinogen I + 4 CO2
-
 ?
4.1.1.37 Uroporphyrinogen III
-
 Rattus norvegicus Coproporphyrinogen III + 4 CO2
-
 ?