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Literature summary extracted from

  • White Tabor, C.; Tabor, H.
    Methionine adenosyltransferase (S-adenosylmethionine synthetase) and S-adenosylmethionine decarboxylase (1984), Adv. Enzymol. Relat. Areas Mol. Biol., 56, 251-282.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.50 1,3-diaminopropane stimulates Rattus norvegicus
4.1.1.50 1,3-diaminopropane stimulates Saccharomyces cerevisiae
4.1.1.50 1,3-diaminopropane activates Saccharomyces cerevisiae
4.1.1.50 cadaverine activates Saccharomyces cerevisiae
4.1.1.50 putrescine required Saccharomyces cerevisiae
4.1.1.50 putrescine stimulation Mus musculus
4.1.1.50 putrescine stimulation Homo sapiens
4.1.1.50 putrescine stimulation Rattus norvegicus
4.1.1.50 putrescine stimulation Saccharomyces cerevisiae
4.1.1.50 putrescine stimulation Lytechinus pictus
4.1.1.50 pyruvate
-
 Homo sapiens
4.1.1.50 pyruvate each subunit contains one covalently linked pyruvate Escherichia coli
4.1.1.50 pyruvate each subunit contains one covalently linked pyruvate Rattus norvegicus
4.1.1.50 pyruvate each subunit contains one covalently linked pyruvate Saccharomyces cerevisiae
4.1.1.50 spermidine
-
 Saccharomyces cerevisiae
4.1.1.50 spermidine
-
 Lytechinus pictus
4.1.1.50 spermidine weak stimulation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.50 (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
-
 Escherichia coli
4.1.1.50 (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
-
 Rattus norvegicus
4.1.1.50 (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
-
 Saccharomyces cerevisiae
4.1.1.50 1,1'-[(Methylethanediylidene)dinitrilo] bis(3-aminoguanidine)
-
 Rattus norvegicus
4.1.1.50 Dimethylglyoxal bis(guanylhydrazone)
-
 Rattus norvegicus
4.1.1.50 ethylglyoxal bis(guanylhydrazone)
-
 Rattus norvegicus
4.1.1.50 methylglyoxal bis(guanylhydrazone) competitive Escherichia coli
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Homo sapiens
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Lytechinus pictus
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Mus musculus
4.1.1.50 methylglyoxal bis(guanylhydrazone) reversible Rattus norvegicus
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Saccharomyces cerevisiae
4.1.1.50 NaBH4
-
 Escherichia coli
4.1.1.50 NaBH4
-
 Saccharomyces cerevisiae
4.1.1.50 NaCNBH3 inactivation in presence of adenosylmethionine and Mg2+, no inactivation in absence of substrate and Mg2+ Escherichia coli
4.1.1.50 NaCNBH3
-
 Rattus norvegicus
4.1.1.50 phenylhydrazine strong Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.50 additional information
-
 additional information
-
 Rattus norvegicus
4.1.1.50 0.06
-
 S-adenosylmethionine
-
 Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.50 Ca2+ requires a divalent cation, Mg2+, Ca2+ or Mn2+ Escherichia coli
4.1.1.50 Mg2+ requires a divalent cation, Mg2+, Ca2+ or Mn2+ Escherichia coli
4.1.1.50 Mn2+ requires a divalent cation, Mg2+, Ca2+ or Mn2+ Escherichia coli
4.1.1.50 Mn2+ affinity for Mn2+ is increased in presence of substrate Escherichia coli
4.1.1.50 additional information no requirement for a divalent metal ion Rattus norvegicus
4.1.1.50 additional information no requirement for a divalent metal ion Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.50 additional information
-
-
 Rattus norvegicus
4.1.1.50 17000
-
 6 * 17000 Escherichia coli
4.1.1.50 41000
-
 2 * 41000, SDS-PAGE Saccharomyces cerevisiae
4.1.1.50 88000
-
 non-denaturing PAGE Saccharomyces cerevisiae
4.1.1.50 108000
-
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine Mus musculus key enzyme in the biosynthetic pathway for spermidine and spermine ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine Escherichia coli key enzyme in the biosynthetic pathway for spermidine and spermine ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine Homo sapiens key enzyme in the biosynthetic pathway for spermidine and spermine ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine Rattus norvegicus key enzyme in the biosynthetic pathway for spermidine and spermine ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine Saccharomyces cerevisiae key enzyme in the biosynthetic pathway for spermidine and spermine ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine Bos taurus key enzyme in the biosynthetic pathway for spermidine and spermine ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine Lytechinus pictus key enzyme in the biosynthetic pathway for spermidine and spermine ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine Mus musculus the enzyme protein turns over very rapidly in growing or differentiating tissues ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine Homo sapiens the enzyme protein turns over very rapidly in growing or differentiating tissues ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine Rattus norvegicus the enzyme protein turns over very rapidly in growing or differentiating tissues ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine Bos taurus the enzyme protein turns over very rapidly in growing or differentiating tissues ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.50 Bos taurus
-
 calf
-
4.1.1.50 Escherichia coli
-
-
-
4.1.1.50 Homo sapiens
-
-
-
4.1.1.50 Lytechinus pictus
-
-
-
4.1.1.50 Mus musculus
-
-
-
4.1.1.50 Rattus norvegicus
-
-
-
4.1.1.50 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.50
-
 Escherichia coli
4.1.1.50
-
 Homo sapiens
4.1.1.50
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.50 egg
-
 Lytechinus pictus
-
4.1.1.50 liver
-
 Mus musculus
-
4.1.1.50 liver
-
 Rattus norvegicus
-
4.1.1.50 liver
-
 Bos taurus
-
4.1.1.50 lymphocyte
-
 Bos taurus
-
4.1.1.50 mammary gland
-
 Mus musculus
-
4.1.1.50 muscle
-
 Rattus norvegicus
-
4.1.1.50 prostate gland
-
 Homo sapiens
-
4.1.1.50 prostate gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.50 Adenosylethionine poor substrate Escherichia coli ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Mus musculus (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Escherichia coli (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Homo sapiens (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Rattus norvegicus (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Saccharomyces cerevisiae (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Bos taurus (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Lytechinus pictus (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine key enzyme in the biosynthetic pathway for spermidine and spermine Mus musculus ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine key enzyme in the biosynthetic pathway for spermidine and spermine Escherichia coli ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine key enzyme in the biosynthetic pathway for spermidine and spermine Homo sapiens ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine key enzyme in the biosynthetic pathway for spermidine and spermine Rattus norvegicus ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine key enzyme in the biosynthetic pathway for spermidine and spermine Saccharomyces cerevisiae ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine key enzyme in the biosynthetic pathway for spermidine and spermine Bos taurus ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine key enzyme in the biosynthetic pathway for spermidine and spermine Lytechinus pictus ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine the enzyme protein turns over very rapidly in growing or differentiating tissues Mus musculus ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine the enzyme protein turns over very rapidly in growing or differentiating tissues Homo sapiens ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine the enzyme protein turns over very rapidly in growing or differentiating tissues Rattus norvegicus ?
-
 ?
4.1.1.50 S-adenosyl-L-methionine the enzyme protein turns over very rapidly in growing or differentiating tissues Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.50 dimer
-
 Mus musculus
4.1.1.50 dimer
-
 Rattus norvegicus
4.1.1.50 dimer 2 * 41000, SDS-PAGE Saccharomyces cerevisiae
4.1.1.50 hexamer 6 * 17000 Escherichia coli
4.1.1.50 More
-
 Rattus norvegicus