EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.362 | glutathione-S-transferase-fusion protein, SET gene | Homo sapiens |
2.1.1.362 | glutathione-S-transferase-fusion protein, SET gene | Drosophila elegans |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.362 | H299A | overlap PCR, destroyed SET gene, no activity remaining | Drosophila elegans |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.1.1.362 | nucleus | - |
Homo sapiens | 5634 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.1.1.362 | 45000 | - |
SDS-PAGE | Homo sapiens |
2.1.1.362 | 45000 | - |
SDS-PAGE | Drosophila elegans |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.362 | additional information | Drosophila melanogaster | - |
? | - |
? | |
2.1.1.362 | additional information | Homo sapiens | histone methylation has significant effects on heterochromatin formation and transcriptional regulation | ? | - |
? | |
2.1.1.362 | additional information | Drosophila elegans | histone methylation has significant effects on heterochromatin formation and transcriptional regulation | ? | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | Drosophila melanogaster | - |
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | Homo sapiens | Lys20 of histone 4, SET8 | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | Drosophila elegans | Lys20 of histone 4, SET8 | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.362 | Drosophila elegans | - |
- |
- |
2.1.1.362 | Drosophila melanogaster | - |
SET8 sequence | - |
2.1.1.362 | Homo sapiens | Q9NQR1 | HeLa cells | - |
2.1.1.362 | Homo sapiens | Q9NQR1 | SET8 sequence | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.362 | partial | Homo sapiens |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | amino acid sequence comparison | Homo sapiens | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | amino acid sequence comparison | Drosophila elegans | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | enzyme is encoded on genes containing the SET-domain sequence, substrate specificity is connected to SET sequence | Drosophila melanogaster | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | enzyme is encoded on genes containing the SET-domain sequence, substrate specificity is connected to SET sequence | Homo sapiens | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | enzyme is encoded on genes containing the SET-domain sequence, substrate specificity is connected to SET sequence | Drosophila elegans |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.362 | additional information | - |
Drosophila melanogaster | ? | - |
? | |
2.1.1.362 | additional information | histone methylation has significant effects on heterochromatin formation and transcriptional regulation | Homo sapiens | ? | - |
? | |
2.1.1.362 | additional information | histone methylation has significant effects on heterochromatin formation and transcriptional regulation | Drosophila elegans | ? | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | - |
Drosophila melanogaster | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | - |
Drosophila elegans | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | high substrate and methylation site specificity | Drosophila melanogaster | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | high substrate and methylation site specificity | Homo sapiens | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | Lys20 of histone 4 | Drosophila melanogaster | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | Lys20 of histone 4 | Homo sapiens | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | Lys20 of histone 4, SET8 | Homo sapiens | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
2.1.1.362 | S-adenosyl-L-methionine + histone L-lysine | Lys20 of histone 4, SET8 | Drosophila elegans | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.1.362 | monomer | 1 * 45000, SDS-PAGE | Homo sapiens |
2.1.1.362 | monomer | 1 * 45000, SDS-PAGE | Drosophila elegans |