EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.2.2 | medicine | - |
Escherichia coli |
2.1.2.2 | medicine | - |
Homo sapiens |
2.1.2.2 | medicine | inhibitor 5,10-dideazatetrahydrofolate is antiproliferate and cytotoxic against mammalian tumor cells in culture and have broad spectrum activity against transplantable mouse tumors and human tumor xenografts | Mus musculus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.2.2 | cDNA, recombinant enzyme expressed in insect cells with a recombinant baculovirus | Mus musculus |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.2.2 | - |
Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.2 | 10-formyl-5,8-dideazafolic acid hexaglutamate | - |
Mus musculus | |
2.1.2.2 | 2',5'-thiophene dideazatetrahydrofolate | LY309887, diastereomer B | Homo sapiens | |
2.1.2.2 | 2',5'-thiophene dideazatetrahydrofolate | LY309887, diastereomer B | Mus musculus | |
2.1.2.2 | 2-deaminodideazatetrahydrofolate | - |
Mus musculus | |
2.1.2.2 | 5,10-dideazatetrahydrofolate | - |
Escherichia coli | |
2.1.2.2 | 5,10-dideazatetrahydrofolate | - |
Homo sapiens | |
2.1.2.2 | 5,10-dideazatetrahydrofolate | - |
Mus musculus | |
2.1.2.2 | 5,8-Dideazafolate | - |
Escherichia coli | |
2.1.2.2 | 5,8-dideazafolate hexaglutamate | - |
Mus musculus | |
2.1.2.2 | 5,8-dideazapteroyl hexaglutamate | - |
Mus musculus | |
2.1.2.2 | 5-deazatetrahydrofolate | - |
Mus musculus | |
2.1.2.2 | dideazatetrahydrofolate | - |
Mus musculus | |
2.1.2.2 | dideazatetrahydrofolate hexaglutamate | - |
Mus musculus | |
2.1.2.2 | homo-dideazatetrahydrofolate | - |
Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.2.2 | 0.000075 | - |
10-formyl-5,8-dideazafolate | recombinant enzyme | Mus musculus | |
2.1.2.2 | 0.0013 | - |
10-formyl-5,8-dideazafolate | - |
Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Gallus gallus | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Mus musculus | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Escherichia coli | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Homo sapiens | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Mus musculus | carries out the second, third and fifth sequential reactions of de novo purine synthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.2 | Escherichia coli | - |
- |
- |
2.1.2.2 | Gallus gallus | - |
chicken | - |
2.1.2.2 | Homo sapiens | - |
human | - |
2.1.2.2 | Mus musculus | - |
mouse | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.2.2 | - |
Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.2.2 | L-1210 cell | murine leukemia | Mus musculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.1.2.2 | 7 | - |
- |
Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.2 | 10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide | - |
Mus musculus | 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide | - |
? | |
2.1.2.2 | 10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide | - |
Escherichia coli | 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide | - |
? | |
2.1.2.2 | 10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide | - |
Homo sapiens | 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Gallus gallus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Escherichia coli | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Gallus gallus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Escherichia coli | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | 10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | carries out the second, third and fifth sequential reactions of de novo purine synthesis pathway | Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
2.1.2.2 | additional information | - |
Escherichia coli | ? | - |
? | |
2.1.2.2 | additional information | trifunctional enzyme, GAR synthetase, aminoimidazole ribonucleotide synthetase and GAR transformylase | Gallus gallus | ? | - |
? | |
2.1.2.2 | additional information | trifunctional enzyme, GAR synthetase, aminoimidazole ribonucleotide synthetase and GAR transformylase | Mus musculus | ? | - |
? | |
2.1.2.2 | additional information | trifunctional enzyme, GAR synthetase, aminoimidazole ribonucleotide synthetase and GAR transformylase | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.2.2 | GARFT | - |
Gallus gallus |
2.1.2.2 | GARFT | - |
Mus musculus |
2.1.2.2 | GARFT | - |
Escherichia coli |
2.1.2.2 | GARFT | - |
Homo sapiens |