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Literature summary extracted from

  • Sugita, T.; Aya, H.; Ueno, M.; Ishizuka, T.; Kawashima, K.
    Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (1997), J. Biochem., 122, 309-313.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.2.3 medicine target for development of inhibitors with potential use as chemotherapeutic agents Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.3 cloned from a placenta cDNA library, overproduced in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.3 4-amino-10-methylpteroylglutamic acid methotrexate, non-competitive inhibitor Homo sapiens
2.1.2.3 dihydrofolic acid pentaglutamate
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.2.3 65000
-
 recombinant enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Salmonella enterica subsp. enterica serovar Typhimurium
-
 tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Bacillus subtilis
-
 tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Homo sapiens penultimate and final steps in the de novo purine biosynthesis pathway tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Bacillus subtilis
-
-
-
2.1.2.3 Homo sapiens
-
 human
-
2.1.2.3 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.3
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.3 CCRF-CEM cell leukemia cell, T lymphoblastoid cell line Homo sapiens
-
2.1.2.3 HeLa cell cervical carcinoma cell line Homo sapiens
-
2.1.2.3 Hep-G2 cell hepatocellular carcinoma cell line Homo sapiens
-
2.1.2.3 liver
-
 Homo sapiens
-
2.1.2.3 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
 Salmonella enterica subsp. enterica serovar Typhimurium tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
 Bacillus subtilis tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide penultimate and final steps in the de novo purine biosynthesis pathway Homo sapiens tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Bacillus subtilis ?
-
 ?
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Homo sapiens ?
-
 ?
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Salmonella enterica subsp. enterica serovar Typhimurium tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Bacillus subtilis tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Homo sapiens tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r