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Literature summary extracted from

  • Wolan, D.W.; Greasley, S.E.; Beardsley, G.P.; Wilson, I.A.
    Structural insights into the avian AICAR transformylase mechanism (2002), Biochemistry, 41, 15505-15513.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.2.3 medicine
-
Gallus sp.
2.1.2.3 medicine target for development of inhibitors with potential use as chemotherapeutic agents Homo sapiens
2.1.2.3 medicine potential target for development of antineoplastic drugs Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.3 ATICcDNA cloned into a pET28a vector and transformed into Escherichia coli BL21.DE3 for overexpression Gallus sp.

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.2.3 ATIC complex crystallized in monoclinic space group P2(1), a = 56.48 A, b = 107.88 A, c = 103.86 A and beta = 91.2° Gallus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.3 4-amino-10-methylpteroylglutamic acid methotrexate, non-competitive inhibitor Gallus sp.
2.1.2.3 4-amino-10-methylpteroylglutamic acid methotrexate, non-competitive inhibitor Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.3 0.0168
-
5-aminoimidazole-4-carboxamide ribonucleotide
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Homo sapiens penultimate and final steps in the de novo purine biosynthesis pathway tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp. penultimate and final steps in the de novo purine biosynthesis pathway tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Gallus sp.
-
avian
-
2.1.2.3 Homo sapiens
-
human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.3
-
Gallus sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide penultimate and final steps in the de novo purine biosynthesis pathway Homo sapiens tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide penultimate and final steps in the de novo purine biosynthesis pathway Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Homo sapiens ?
-
?
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Gallus sp. ?
-
?
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
Homo sapiens tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
r
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
Gallus sp. tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
r

Subunits

EC Number Subunits Comment Organism
2.1.2.3 dimer
-
Homo sapiens
2.1.2.3 dimer
-
Gallus sp.

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.3 N10-formyltetrahydrofolate
-
Homo sapiens
2.1.2.3 N10-formyltetrahydrofolate
-
Gallus sp.