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Literature summary extracted from

  • Mathews, C.K.; Wheeler, L.J.; Ungermann, C.; Young, J.P.; Ray, N.B.
    Enzyme interactions involving T4 phage-coded thymidylate synthase and deoxycytidylate hydroxymethylase (1993), Adv. Exp. Med. Biol., 338, 563-570.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.8 structural gene 42 encodes enzyme Tequatrovirus T4

Protein Variants

EC Number Protein Variants Comment Organism
2.1.2.8 additional information gene 42 amber mutants synthesize truncated forms of enzyme Tequatrovirus T4

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.8 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate Tequatrovirus T4
-
 tetrahydrofolate + 5-hydroxymethyldeoxycytidylate enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage ?
2.1.2.8 additional information Tequatrovirus T4 enzyme is part of the dNTP synthetase complex ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.8 Tequatrovirus T4
-
 Escherichia coli infected with bacteriophage T4
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.8 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
-
 Tequatrovirus T4 tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
 ?
2.1.2.8 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
-
 Tequatrovirus T4 tetrahydrofolate + 5-hydroxymethyldeoxycytidylate enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage ?
2.1.2.8 additional information enzyme is part of the dNTP synthetase complex Tequatrovirus T4 ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.8 5,10-methylenetetrahydrofolate
-
 Tequatrovirus T4
2.1.2.8 tetrahydrofolate
-
 Tequatrovirus T4