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Literature summary extracted from

  • Farrell, S.O.; Fiol, C.J.; Reddy, J.K.; Bieber, L.L.
    Properties of purified carnitine acyltransferases of mouse liver peroxisomes (1984), J. Biol. Chem., 259, 13089-13095.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.137 5,5'-dithiobis(2-nitrobenzoate) retains its maximum activity when preincubated at pH 7.0 or 8.5 Mus musculus

General Stability

EC Number General Stability Organism
2.3.1.7 proteolytic degradation can occur during purification from liver Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.7 D-carnitine
-
 Bos taurus
2.3.1.7 D-carnitine
-
 Mus musculus
2.3.1.7 malonyl-CoA
-
 Rattus norvegicus
2.3.1.7 Zn2+
-
 Bos taurus
2.3.1.7 Zn2+ inhibition only in reverse direction Mus musculus
2.3.1.137 D-carnitine
-
 Mus musculus
2.3.1.137 D-carnitine
-
 Rattus norvegicus
2.3.1.137 Trypsin
-
 Mus musculus
2.3.1.137 Zn2+ inhibits enzyme in reverse direction Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.7 0.0153
-
 CoASH
-
 Mus musculus
2.3.1.7 0.0191
-
 octanoyl-CoA
-
 Mus musculus
2.3.1.7 0.02
-
 hexanoyl-CoA
-
 Mus musculus
2.3.1.7 0.0287
-
 decanoyl-CoA
-
 Mus musculus
2.3.1.7 0.086
-
 carnitine
-
 Mus musculus
2.3.1.7 0.121
-
 L-carnitine cosubstrate butanoyl-CoA Mus musculus
2.3.1.7 0.344
-
 L-carnitine cosubstrate hexanoyl-CoA Mus musculus
2.3.1.7 0.395
-
 L-carnitine cosubstrate octanoyl-CoA Mus musculus
2.3.1.7 0.519
-
 L-carnitine cosubstrate decanoyl-CoA Mus musculus
2.3.1.137 0.1
-
 L-octanoylcarnitine
-
 Mus musculus
2.3.1.137 0.104
-
 L-palmitoylcarnitine
-
 Mus musculus
2.3.1.137 0.11
-
 CoASH
-
 Mus musculus
2.3.1.137 0.783
-
 acetyl-L-carnitine
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.7 mitochondrion
-
 Mus musculus 5739
-
2.3.1.7 mitochondrion
-
 Rattus norvegicus 5739
-
2.3.1.7 mitochondrion
-
 Torulopsis bovina 5739
-
2.3.1.7 peroxisome
-
 Mus musculus 5777
-
2.3.1.7 peroxisome
-
 Rattus norvegicus 5777
-
2.3.1.137 microsome
-
 Mus musculus
-
-
2.3.1.137 microsome
-
 Rattus norvegicus
-
-
2.3.1.137 microsome
-
 Bos taurus
-
-
2.3.1.137 mitochondrion
-
 Mus musculus 5739
-
2.3.1.137 mitochondrion
-
 Rattus norvegicus 5739
-
2.3.1.137 mitochondrion
-
 Bos taurus 5739
-
2.3.1.137 peroxisome
-
 Mus musculus 5777
-
2.3.1.137 peroxisome
-
 Rattus norvegicus 5777
-
2.3.1.137 peroxisome
-
 Bos taurus 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.7 25000
-
 1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE Rattus norvegicus
2.3.1.7 34000
-
 1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE Rattus norvegicus
2.3.1.7 60000
-
 gel filtration Mus musculus
2.3.1.137 60000
-
 gel filtration Mus musculus
2.3.1.137 66000
-
-
 Rattus norvegicus
2.3.1.137 66000
-
 gel filtration Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine Mus musculus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Rattus norvegicus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Bos taurus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Mus musculus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Rattus norvegicus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Bos taurus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Torulopsis bovina
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH Mus musculus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Rattus norvegicus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Bos taurus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Torulopsis bovina
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Mus musculus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Rattus norvegicus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Bos taurus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.137 acyl-CoA + L-carnitine Mus musculus
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine Rattus norvegicus
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine Bos taurus
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine Canis lupus familiaris
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine Rattus norvegicus Sprague-Dawley
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-L-carnitine + CoA Mus musculus
-
 acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA Rattus norvegicus
-
 acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA Bos taurus
-
 acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA Canis lupus familiaris
-
 acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA Rattus norvegicus Sprague-Dawley
-
 acyl-CoA + L-carnitine
-
 r
2.3.1.137 L-carnitine + octanoyl-CoA Mus musculus
-
 octanoyl-L-carnitine + CoA
-
 r
2.3.1.137 L-carnitine + octanoyl-CoA Rattus norvegicus
-
 octanoyl-L-carnitine + CoA
-
 r
2.3.1.137 L-carnitine + octanoyl-CoA Bos taurus
-
 octanoyl-L-carnitine + CoA
-
 r
2.3.1.137 L-carnitine + octanoyl-CoA Rattus norvegicus Sprague-Dawley
-
 octanoyl-L-carnitine + CoA
-
 r
2.3.1.137 octanoyl-L-carnitine + CoA Rattus norvegicus
-
 L-carnitine + octanoyl-CoA
-
 r
2.3.1.137 octanoyl-L-carnitine + CoA Bos taurus
-
 L-carnitine + octanoyl-CoA
-
 r
2.3.1.137 octanoyl-L-carnitine + CoA Mus musculus reverse reaction L-carnitine + octanoyl-CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Bos taurus
-
 beef
-
2.3.1.7 Mus musculus
-
 mouse
-
2.3.1.7 Mus musculus
-
 swiss mice
-
2.3.1.7 Rattus norvegicus
-
 rat
-
2.3.1.7 Rattus norvegicus
-
 Sprague-Dawley
-
2.3.1.7 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-
2.3.1.7 Torulopsis bovina
-
-
-
2.3.1.137 Bos taurus
-
 beef
-
2.3.1.137 Canis lupus familiaris
-
 dog
-
2.3.1.137 Mus musculus
-
 mouse
-
2.3.1.137 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.7
-
 Mus musculus
2.3.1.137
-
 Mus musculus
2.3.1.137
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.7 heart
-
 Mus musculus
-
2.3.1.7 heart
-
 Rattus norvegicus
-
2.3.1.7 heart
-
 Bos taurus
-
2.3.1.7 liver
-
 Mus musculus
-
2.3.1.7 liver
-
 Rattus norvegicus
-
2.3.1.137 intestine
-
 Mus musculus
-
2.3.1.137 kidney
-
 Mus musculus
-
2.3.1.137 liver
-
 Mus musculus
-
2.3.1.137 liver
-
 Rattus norvegicus
-
2.3.1.137 liver
-
 Bos taurus
-
2.3.1.137 liver
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine
-
 Mus musculus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Rattus norvegicus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Bos taurus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Mus musculus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Rattus norvegicus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Bos taurus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Torulopsis bovina O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Mus musculus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Rattus norvegicus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Bos taurus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Torulopsis bovina acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Mus musculus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Rattus norvegicus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Bos taurus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Torulopsis bovina acyl-CoA + carnitine
-
 r
2.3.1.7 decanoyl-CoA + carnitine
-
 Mus musculus decanoylcarnitine + CoASH
-
 r
2.3.1.7 decanoyl-CoA + carnitine
-
 Rattus norvegicus decanoylcarnitine + CoASH
-
 r
2.3.1.7 decanoylcarnitine + CoASH
-
 Mus musculus decanoyl-CoA + carnitine
-
 r
2.3.1.7 decanoylcarnitine + CoASH
-
 Rattus norvegicus decanoyl-CoA + carnitine
-
 r
2.3.1.7 hexanoyl-CoA + carnitine
-
 Mus musculus hexanoylcarnitine + CoASH
-
 r
2.3.1.7 hexanoyl-CoA + carnitine
-
 Rattus norvegicus hexanoylcarnitine + CoASH
-
 r
2.3.1.7 hexanoylcarnitine + CoASH
-
 Mus musculus hexanoyl-CoA + carnitine
-
 r
2.3.1.7 hexanoylcarnitine + CoASH
-
 Rattus norvegicus hexanoyl-CoA + carnitine
-
 r
2.3.1.7 additional information
-
 Rattus norvegicus ?
-
 ?
2.3.1.7 additional information no carnitine acyltransferase activity with acyl CoAs of carbon chain lengths greater than 3 Torulopsis bovina ?
-
 ?
2.3.1.7 n-butyryl-CoA + carnitine
-
 Mus musculus n-butyrylcarnitine + CoASH
-
 r
2.3.1.7 n-butyryl-CoA + carnitine
-
 Rattus norvegicus n-butyrylcarnitine + CoASH
-
 r
2.3.1.7 n-butyryl-CoA + carnitine
-
 Bos taurus n-butyrylcarnitine + CoASH
-
 r
2.3.1.7 n-butyrylcarnitine + CoASH
-
 Mus musculus n-butyryl-CoA + carnitine
-
 r
2.3.1.7 n-butyrylcarnitine + CoASH
-
 Rattus norvegicus n-butyryl-CoA + carnitine
-
 r
2.3.1.7 n-butyrylcarnitine + CoASH
-
 Bos taurus n-butyryl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Mus musculus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Rattus norvegicus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Bos taurus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Torulopsis bovina acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Mus musculus acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Rattus norvegicus acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Bos taurus acetyl-CoA + carnitine
-
 r
2.3.1.7 octanoyl-CoA + carnitine
-
 Mus musculus octanoylcarnitine + CoASH
-
 r
2.3.1.7 octanoyl-CoA + carnitine
-
 Rattus norvegicus octanoylcarnitine + CoASH
-
 r
2.3.1.7 octanoyl-CoA + carnitine
-
 Bos taurus octanoylcarnitine + CoASH
-
 r
2.3.1.7 octanoylcarnitine + CoASH
-
 Mus musculus octanoyl-CoA + carnitine
-
 r
2.3.1.7 octanoylcarnitine + CoASH
-
 Rattus norvegicus octanoyl-CoA + carnitine
-
 r
2.3.1.7 octanoylcarnitine + CoASH
-
 Bos taurus octanoyl-CoA + carnitine
-
 r
2.3.1.7 propionyl-CoA + L-(-)carnitine
-
 Mus musculus propionylcarnitine + CoASH
-
 r
2.3.1.7 propionyl-CoA + L-(-)carnitine
-
 Rattus norvegicus propionylcarnitine + CoASH
-
 r
2.3.1.7 propionyl-CoA + L-(-)carnitine
-
 Bos taurus propionylcarnitine + CoASH
-
 r
2.3.1.7 propionylcarnitine + CoASH
-
 Mus musculus propionyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 propionylcarnitine + CoASH
-
 Rattus norvegicus propionyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 propionylcarnitine + CoASH
-
 Bos taurus propionyl-CoA + L-(-)carnitine
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Mus musculus acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Rattus norvegicus acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Bos taurus acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Canis lupus familiaris acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Rattus norvegicus Sprague-Dawley acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Mus musculus acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Rattus norvegicus acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Bos taurus acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Canis lupus familiaris acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Rattus norvegicus Sprague-Dawley acyl-CoA + L-carnitine
-
 r
2.3.1.137 CoA + L-octanoylcarnitine
-
 Mus musculus octanoyl-CoA + L-carnitine
-
 ?
2.3.1.137 CoA + L-palmitoylcarnitine
-
 Mus musculus palmitoyl-CoA + L-carnitine
-
 r
2.3.1.137 hexanoyl-CoA + L-carnitine
-
 Mus musculus CoA + L-hexanoylcarnitine
-
 r
2.3.1.137 hexanoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-hexanoylcarnitine
-
 r
2.3.1.137 hexanoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-hexanoylcarnitine
-
 r
2.3.1.137 hexanoyl-CoA + L-carnitine
-
 Rattus norvegicus Sprague-Dawley CoA + L-hexanoylcarnitine
-
 r
2.3.1.137 L-carnitine + octanoyl-CoA
-
 Mus musculus octanoyl-L-carnitine + CoA
-
 r
2.3.1.137 L-carnitine + octanoyl-CoA
-
 Rattus norvegicus octanoyl-L-carnitine + CoA
-
 r
2.3.1.137 L-carnitine + octanoyl-CoA
-
 Bos taurus octanoyl-L-carnitine + CoA
-
 r
2.3.1.137 L-carnitine + octanoyl-CoA
-
 Rattus norvegicus Sprague-Dawley octanoyl-L-carnitine + CoA
-
 r
2.3.1.137 L-hexanoylcarnitine + CoA
-
 Mus musculus hexanoyl-CoA + L-carnitine
-
 r
2.3.1.137 L-hexanoylcarnitine + CoA
-
 Rattus norvegicus hexanoyl-CoA + L-carnitine
-
 r
2.3.1.137 L-hexanoylcarnitine + CoA
-
 Bos taurus hexanoyl-CoA + L-carnitine
-
 r
2.3.1.137 L-hexanoylcarnitine + CoA
-
 Rattus norvegicus Sprague-Dawley hexanoyl-CoA + L-carnitine
-
 r
2.3.1.137 additional information malonyl-CoA is not a substrate Mus musculus ?
-
 ?
2.3.1.137 octanoyl-L-carnitine + CoA
-
 Rattus norvegicus L-carnitine + octanoyl-CoA
-
 r
2.3.1.137 octanoyl-L-carnitine + CoA
-
 Bos taurus L-carnitine + octanoyl-CoA
-
 r
2.3.1.137 octanoyl-L-carnitine + CoA reverse reaction Mus musculus L-carnitine + octanoyl-CoA
-
 r

Subunits

EC Number Subunits Comment Organism
2.3.1.7 dimer 1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE Rattus norvegicus
2.3.1.7 monomer
-
 Rattus norvegicus
2.3.1.7 monomer
-
 Bos taurus
2.3.1.7 monomer 1 * 60000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.3.1.7 CAT
-
 Mus musculus
2.3.1.7 CAT
-
 Rattus norvegicus
2.3.1.137 COT
-
 Mus musculus
2.3.1.137 COT
-
 Rattus norvegicus
2.3.1.137 COT
-
 Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.7 8.5
-
-
 Mus musculus
2.3.1.137 8
-
-
 Mus musculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.7 5.5 10
-
 Mus musculus
2.3.1.137 5.5 10
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.7 1
-
 D-carnitine
-
 Mus musculus
2.3.1.137 0.84
-
 D-carnitine
-
 Mus musculus