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Literature summary extracted from

  • Dimroth, P.; Ringelmann, E.; Lynen, F.
    6-Methylsalicylic acid synthetase from Penicillium patulum. Some catalytic properties of the enzyme and its relation to fatty acid synthetase (1976), Eur. J. Biochem., 68, 591-596.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.3.1.165 activity is lost upon storage Penicillium griseofulvum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.165 iodoacetamide 0.5 mM, complete inactivation of synthetase activity after 15 min at 0°C, enzyme is then able to decarboxlate malonyl-CoA Penicillium griseofulvum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.165 acetyl-CoA + malonyl-CoA + NADPH Penicillium griseofulvum
-
 6-methylsalicylate + CoA + CO2 + NADP+
-
 ?
2.3.1.165 acetyl-CoA + malonyl-CoA + NADPH Penicillium griseofulvum NRRL 2159A
-
 6-methylsalicylate + CoA + CO2 + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.165 Penicillium griseofulvum
-
 NRRL 2159A
-
2.3.1.165 Penicillium griseofulvum NRRL 2159A
-
 NRRL 2159A
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.165 acetyl-CoA + malonyl-CoA + NADPH
-
 Penicillium griseofulvum 6-methylsalicylate + CoA + CO2 + NADP+
-
 ?
2.3.1.165 acetyl-CoA + malonyl-CoA + NADPH
-
 Penicillium griseofulvum NRRL 2159A 6-methylsalicylate + CoA + CO2 + NADP+
-
 ?
2.3.1.165 acetyl-CoA + pantetheine
-
 Penicillium griseofulvum acetyl pantetheine + CoA
-
 ?
2.3.1.165 acetyl-CoA + pantetheine
-
 Penicillium griseofulvum NRRL 2159A acetyl pantetheine + CoA
-
 ?
2.3.1.165 propionyl-CoA + malonyl-CoA + NADPH
-
 Penicillium griseofulvum 6-ethylsalicylate + CoA + CO2 + NADP+
-
 ?
2.3.1.165 propionyl-CoA + malonyl-CoA + NADPH
-
 Penicillium griseofulvum NRRL 2159A 6-ethylsalicylate + CoA + CO2 + NADP+
-
 ?
2.3.1.165 propionyl-CoA + pantetheine 13 times slower rate compared to acetyl-CoA Penicillium griseofulvum propionyl pantetheine + CoA
-
 ?
2.3.1.165 propionyl-CoA + pantetheine 13 times slower rate compared to acetyl-CoA Penicillium griseofulvum NRRL 2159A propionyl pantetheine + CoA
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.165 NADPH
-
 Penicillium griseofulvum