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Literature summary extracted from

  • Yamada, S.; Tanaka, Y.; Furuichi, M.
    Partial purification and characterization of histidine acetyltransferase in brain of Nile tilapia (Oreochromis niloticus) (1995), Biochim. Biophys. Acta, 1245, 239-247.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.33 2-mercaptoethanol slightly inhibitory Oreochromis niloticus
2.3.1.33 Co2+
-
 Oreochromis niloticus
2.3.1.33 coenzyme A
-
 Oreochromis niloticus
2.3.1.33 Cu2+ complete inhibition Oreochromis niloticus
2.3.1.33 dithiothreitol
-
 Oreochromis niloticus
2.3.1.33 Hg2+ strong inhibition Oreochromis niloticus
2.3.1.33 hydroxylamine slightly inhibitory Oreochromis niloticus
2.3.1.33 additional information no inhibition by EDTA, Cd2+, Mg2+, Mn2+, Sr2+, Ca2+, Pb2+ Oreochromis niloticus
2.3.1.33 N-ethylmaleimide
-
 Oreochromis niloticus
2.3.1.33 N-ethylmorpholine-HCl buffer slightly inhibitory Oreochromis niloticus
2.3.1.33 Ni2+ strong inhibition Oreochromis niloticus
2.3.1.33 o-phenanthroline slightly inhibitory Oreochromis niloticus
2.3.1.33 p-chloromercuribenzoate strong inhibition Oreochromis niloticus
2.3.1.33 Tris-HCl buffer slightly inhibitory Oreochromis niloticus
2.3.1.33 Zn2+
-
 Oreochromis niloticus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.33 0.027
-
 acetylcoenzyme A
-
 Oreochromis niloticus
2.3.1.33 0.45
-
 L-histidine
-
 Oreochromis niloticus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.33 Fe2+ stimulates Oreochromis niloticus
2.3.1.33 additional information no divalent metal ions required Oreochromis niloticus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.33 38500
-
 1 * 38500, SDS-PAGE Oreochromis niloticus
2.3.1.33 39000
-
 gel filtration Oreochromis niloticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.33 acetyl-CoA + L-histidine Oreochromis niloticus
-
 CoA + N-acetyl-L-histidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.33 Oreochromis niloticus
-
 Nile tilapia
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.33 partial Oreochromis niloticus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.33 brain
-
 Oreochromis niloticus
-
2.3.1.33 lens
-
 Oreochromis niloticus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.33 additional information
-
 tissue distribution Oreochromis niloticus
2.3.1.33 4.3
-
 partially purified enzyme Oreochromis niloticus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.33 acetyl-CoA + 1-methyl-L-histidine 23% activity compared to that with L-histidine Oreochromis niloticus CoA + 1-methyl-N-acetyl-L-histidine
-
 ?
2.3.1.33 acetyl-CoA + 3-methyl-L-histidine 71% activity compared to that with L-histidine Oreochromis niloticus CoA + 3-methyl-N-acetyl-L-histidine
-
 ?
2.3.1.33 acetyl-CoA + L-histidine
-
 Oreochromis niloticus CoA + N-acetyl-L-histidine
-
 ?
2.3.1.33 acetyl-CoA + L-histidine strictly specific for the substrates Oreochromis niloticus CoA + N-acetyl-L-histidine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.33 monomer 1 * 38500, SDS-PAGE Oreochromis niloticus

Synonyms

EC Number Synonyms Comment Organism
2.3.1.33 HISAT
-
 Oreochromis niloticus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.33 37
-
-
 Oreochromis niloticus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.3.1.33 37 50 37°C: optimum, 50°C: less than 10% activity Oreochromis niloticus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.33 7 9.5 broad optimum, assay at pH 7.8 Oreochromis niloticus