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Literature summary extracted from

  • Alberts, A.W.; Bell, R.M.; Vagelos, P.R.
    Acyl carrier protein. XV. Studies of beta-ketoacyl-acyl carrier protein synthetase (1972), J. Biol. Chem., 247, 3190-3198.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.41 iodoacetamide acyl-[acyl-carrier-protein]-derivatives, e.g. acetyl-[acyl-carrier-protein], hexanoyl-CoA, octanoyl-CoA, decanoyl-CoA protect Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.41 0.04
-
 acetyl-[acyl-carrier protein] acyl-carrier-protein, fatty acyl transfer between tetradecanoyl-CoA and acyl-carrier-protein Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.41 acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] Escherichia coli involved in biosynthesis of saturated fatty acids 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.41 Escherichia coli
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.41 9.7
-
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.41 acyl-CoA + [acyl-carrier protein] tetradecanoyl-CoA and cis-9-hexadecenoyl-CoA are poor substrates Escherichia coli acyl-[acyl-carrier protein] + CoA
-
 r
2.3.1.41 acyl-CoA + [acyl-carrier protein] catalyzes fatty acyl transfer between CoA and [acyl-carrier-protein], but no direct transfer to the enzyme as with acyl-[acyl-carrier-protein] Escherichia coli acyl-[acyl-carrier protein] + CoA
-
 r
2.3.1.41 acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] involved in biosynthesis of saturated fatty acids Escherichia coli 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
 r
2.3.1.41 cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
 Escherichia coli 3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
 r
2.3.1.41 cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] not cis-vaccenoyl-[acyl-carrier-protein], i.e. cis-11-octenoyl-[acyl-carrier-protein] Escherichia coli cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
 r
2.3.1.41 cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] from C-10 to C-16, e.g. cis-5-decenoyl-[acyl-carrier-protein], cis-5-dodecenoyl-[acyl-carrier-protein], cis-7-tetradecenoyl-[acyl-carrier-protein], cis-9-hexenoyl-[acyl-carrier-protein], i.e. palmitoleoyl-[acyl-carrier-protein], poor substrates Escherichia coli cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
 r
2.3.1.41 hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
 Escherichia coli 3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
 r
2.3.1.41 malonyl-[acyl-carrier protein] catalyzes malonyl-[acyl-carrier-protein] decarboxylation independent of fatty acyl-[acyl-carrier-protein] Escherichia coli acetyl-[acyl-carrier protein] + CO2
-
 ?
2.3.1.41 additional information enzyme also catalyzes a malonyl-CoA-CO2 exchange reaction, overview: substrates and kinetics Escherichia coli ?
-
 ?
2.3.1.41 saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] substrate specificity, overview Escherichia coli 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
 r
2.3.1.41 tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] poor substrate Escherichia coli 3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.41 37
-
 assay at Escherichia coli