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Literature summary extracted from

  • Morrissey, J.J.; Edwards, S.B.; Lovenberg, W.
    Comparison of rat pineal gland and rat liver serotonin-N-acetyltransferase (1977), Biochem. Biophys. Res. Commun., 77, 118-123.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.3.1.5 cysteamine stabilizes Rattus norvegicus
2.3.1.87 cysteamine stabilizes Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.5 0.05
-
 acetyl-CoA
-
 Rattus norvegicus
2.3.1.5 0.11 0.125 acetyl-CoA
-
 Rattus norvegicus
2.3.1.5 0.24 0.25 tryptamine liver Rattus norvegicus
2.3.1.87 0.05
-
 acetyl-CoA cosubstrate tryptamine, pineal gland Rattus norvegicus
2.3.1.87 0.125
-
 acetyl-CoA cosubstrate tryptamine, liver Rattus norvegicus
2.3.1.87 0.24
-
 tryptamine liver Rattus norvegicus
2.3.1.87 0.53
-
 tryptamine pineal gland Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.87 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.5 10000
-
 4 * 10000, pineal gland, gel filtration in the presence of cysteamine Rattus norvegicus
2.3.1.5 12000
-
 2 * 12000, liver, gel filtration in the presence of cysteamine Rattus norvegicus
2.3.1.5 26000
-
 liver, gel filtration Rattus norvegicus
2.3.1.5 39000
-
 pineal gland, gel filtration Rattus norvegicus
2.3.1.87 10000
-
 4 * 10000, pineal gland, gel filtration in the presence of cysteamine Rattus norvegicus
2.3.1.87 12000
-
 2 * 12000, liver, gel filtration in the presence of cysteamine Rattus norvegicus
2.3.1.87 26000
-
 liver, gel filtration Rattus norvegicus
2.3.1.87 39000
-
 pineal gland, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.5 acetyl-CoA + an arylamine Rattus norvegicus constitutive enzyme CoA + a N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + an arylamine Rattus norvegicus pineal gland: inducible CoA + a N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + an arylamine Rattus norvegicus Sprague-Dawley constitutive enzyme CoA + a N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + an arylamine Rattus norvegicus Sprague-Dawley pineal gland: inducible CoA + a N-acetylarylamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Rattus norvegicus
-
 Sprague-Dawley
-
2.3.1.5 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-
2.3.1.87 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.87
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.5 acetyl-CoA + an arylamine = CoA + an N-acetylarylamine ping-pong bi-bi mechanism Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.5 liver
-
 Rattus norvegicus
-
2.3.1.5 pineal gland
-
 Rattus norvegicus
-
2.3.1.87 liver non-inducible Rattus norvegicus
-
2.3.1.87 pineal gland inducible Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + an arylamine constitutive enzyme Rattus norvegicus CoA + a N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + an arylamine pineal gland: inducible Rattus norvegicus CoA + a N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + an arylamine constitutive enzyme Rattus norvegicus Sprague-Dawley CoA + a N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + an arylamine pineal gland: inducible Rattus norvegicus Sprague-Dawley CoA + a N-acetylarylamine
-
 ?
2.3.1.5 acetyl-CoA + tryptamine
-
 Rattus norvegicus CoA + N-acetyltryptamine
-
 ?
2.3.1.5 acetyl-CoA + tryptamine
-
 Rattus norvegicus Sprague-Dawley CoA + N-acetyltryptamine
-
 ?
2.3.1.87 acetyl-CoA + tryptamine
-
 Rattus norvegicus CoA + N-acetyltryptamine
-
 ?
2.3.1.87 acetyl-CoA + tryptamine
-
 Rattus norvegicus Sprague-Dawley CoA + N-acetyltryptamine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.5 dimer 2 * 12000, liver, gel filtration in the presence of cysteamine Rattus norvegicus
2.3.1.5 tetramer 4 * 10000, pineal gland, gel filtration in the presence of cysteamine Rattus norvegicus
2.3.1.87 dimer 2 * 12000, liver, gel filtration in the presence of cysteamine Rattus norvegicus
2.3.1.87 tetramer 4 * 10000, pineal gland, gel filtration in the presence of cysteamine Rattus norvegicus