Literature summary extracted from

Banuelos, O.; Casqueiro, J.; Gutierrez, S.; Martin, J.F.
Overexpression of the lys1 gene in Penicillium chrysogenum: homocitrate synthase levels, alpha-aminoadipic acid pool and penicillin production (2000), Appl. Microbiol. Biotechnol., 54, 69-77.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.3.3.14	overexpression in Penicillium chrysogenum using additional copies of lys1 with its own promoter or under the control of the pcbC promoter in either autonomously replicating or integrative vectors. Tranformants containing 3 to 32 additional copies of the lys1 gene are selected	Penicillium chrysogenum

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.3.3.14	acetyl-CoA + H2O + 2-oxoglutarate	Penicillium chrysogenum	the enzyme catalyzes the first step of the lysine and penicillin pathway and is highly sensitive to feedback regulation by L-lysine	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.3.14	Penicillium chrysogenum	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.3.14	acetyl-CoA + H2O + 2-oxoglutarate	-	Penicillium chrysogenum	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?
2.3.3.14	acetyl-CoA + H2O + 2-oxoglutarate	the enzyme catalyzes the first step of the lysine and penicillin pathway and is highly sensitive to feedback regulation by L-lysine	Penicillium chrysogenum	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?

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Release 2023.1 (January 2023)