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Literature summary extracted from

  • Stoychev, G.; Kierdaszuk, B.; Shugar, D.
    Xanthosine and xanthine. Substrate properties with purine nucleoside phosphorylases, and relevance to other enzyme systems (2002), Eur. J. Biochem., 269, 4048-4057.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.1 guanine inhibits phosphorolysis of xanthosine Bos taurus
2.4.2.1 guanine inhibits phosphorolysis of xanthosine Homo sapiens
2.4.2.1 guanosine inhibits phosphorolysis of xynthosine Bos taurus
2.4.2.1 guanosine inhibits phosphorolysis of xynthosine Homo sapiens
2.4.2.1 hypoxanthine inhibits phosphorolysis of xanthosine Bos taurus
2.4.2.1 hypoxanthine inhibits phosphorolysis of xanthosine Homo sapiens
2.4.2.1 xanthine poor inhibitor of phosphorolysis of guanosine Bos taurus
2.4.2.1 xanthine poor inhibitor of phosphorolysis of guanosine Homo sapiens
2.4.2.1 Xanthosine poor inhibitor of phosphorolysis of guanosine Bos taurus
2.4.2.1 Xanthosine poor inhibitor of phosphorolysis of guanosine Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.1 0.006
-
 guanine pH 7.0 Homo sapiens
2.4.2.1 0.009
-
 guanine pH 7.5 Homo sapiens
2.4.2.1 0.011
-
 guanosine pH 7.0 Bos taurus
2.4.2.1 0.011
-
 guanine pH 6.0 Bos taurus
2.4.2.1 0.012
-
 guanosine pH 7.0 Homo sapiens
2.4.2.1 0.0138
-
 guanine pH 7.0 Homo sapiens
2.4.2.1 0.014
-
 guanosine pH 6.5 Homo sapiens
2.4.2.1 0.0159
-
 guanosine pH 6.5 Bos taurus
2.4.2.1 0.022
-
 guanine pH 7.5 Homo sapiens
2.4.2.1 0.029
-
 guanine pH 6.0 Homo sapiens
2.4.2.1 0.046
-
 guanosine pH 5.7 Bos taurus
2.4.2.1 0.091
-
 guanosine pH 5.7 Homo sapiens
2.4.2.1 0.28
-
 xanthine pH 6.0 Bos taurus
2.4.2.1 0.306
-
 xanthine pH 7.5 Bos taurus
2.4.2.1 0.38
-
 xanthine pH 6.0 Homo sapiens
2.4.2.1 0.4
-
 Xanthosine pH 5.7 Bos taurus
2.4.2.1 0.425
-
 xanthine pH 7.0 Homo sapiens
2.4.2.1 0.58
-
 Xanthosine pH 5.7 Homo sapiens
2.4.2.1 1.1
-
 Xanthosine pH 6.5 Bos taurus
2.4.2.1 1.6
-
 Xanthosine pH 6.5 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.1 Bos taurus P55859
-
-
2.4.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.1 erythrocyte
-
 Homo sapiens
-
2.4.2.1 spleen
-
 Homo sapiens
-
2.4.2.1 spleen
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.1 6-thioxanthine + alpha-D-ribose 1-phosphate
-
 Homo sapiens 6-thioxanthosine + phosphate
-
 ?
2.4.2.1 6-thioxanthine + alpha-D-ribose 1-phosphate
-
 Bos taurus 6-thioxanthosine + phosphate
-
 ?
2.4.2.1 guanosine + phosphate
-
 Homo sapiens guanine + alpha-D-ribose 1-phosphate
-
 r
2.4.2.1 guanosine + phosphate
-
 Bos taurus guanine + alpha-D-ribose 1-phosphate
-
 r
2.4.2.1 inosine + phosphate
-
 Homo sapiens hypoxanthine + alpha-D-ribose 1-phosphate
-
 r
2.4.2.1 inosine + phosphate
-
 Bos taurus hypoxanthine + alpha-D-ribose 1-phosphate
-
 r
2.4.2.1 xanthosine + arsenate
-
 Homo sapiens xanthine + alpha-D-ribose 1-arsenate
-
 ?
2.4.2.1 xanthosine + arsenate
-
 Bos taurus xanthine + alpha-D-ribose 1-arsenate
-
 ?
2.4.2.1 xanthosine + phosphate
-
 Homo sapiens alpha-D-ribose 1-phosphate + xanthine
-
 r
2.4.2.1 xanthosine + phosphate
-
 Bos taurus alpha-D-ribose 1-phosphate + xanthine
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.1 5 6 reaction with xanthine or xanthosine Homo sapiens
2.4.2.1 5 6 reaction with xanthine or xanthosine Bos taurus
2.4.2.1 7 8 reaction with guanine, guanosine, hypoxanthine and inosine Homo sapiens
2.4.2.1 7 8 reaction with guanine, guanosine, hypoxanthine and inosine Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.1 0.004
-
 guanine inhibition of phosphorolysis of xanthosine Homo sapiens
2.4.2.1 0.007
-
 hypoxanthine inhibition of phosphorolysis of xanthosine Homo sapiens
2.4.2.1 0.01
-
 guanosine inhibition of phosphorolysis of xanthosine Homo sapiens