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Literature summary extracted from
- Purine nucleoside phosphorylases: properties, functions, and clinical aspects (2000), Pharmacol. Ther., 88, 349-425.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 2.4.2.1 | medicine | - |
Plasmodium falciparum |
| 2.4.2.1 | medicine | - |
Bos taurus |
| 2.4.2.1 | medicine | - |
Escherichia coli |
| 2.4.2.1 | medicine | overview of clinical aspects | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.4.2.1 | 2-amino-6-chloro-7-deazapurine 2'-deoxyriboside | - |
Escherichia coli |  |
| 2.4.2.1 | 2-chloro-6-(3-phenyl-1-propoxy)purine | - |
Escherichia coli | |
| 2.4.2.1 | 5'-deoxy-5'-iodo-9-deazainosine | - |
Homo sapiens | |
| 2.4.2.1 | 5'-deoxy-5'-iodoinosine | - |
Homo sapiens | |
| 2.4.2.1 | 6-amino-2-chloro-7-deazapurine 2'-deoxyriboside | - |
Escherichia coli | |
| 2.4.2.1 | 6-amino-7-phenylethinyl-7-deazapurine 2'-deoxyriboside | - |
Escherichia coli | |
| 2.4.2.1 | 6-benzyloxy-2-chloropurine | - |
Escherichia coli | |
| 2.4.2.1 | 6-chloro-7-deazapurine 2'-deoxyriboside | - |
Escherichia coli | |
| 2.4.2.1 | 6-methylformycin | - |
Escherichia coli | |
| 2.4.2.1 | 8-amino-3-(2-thienylmethyl)guanine | - |
Homo sapiens | |
| 2.4.2.1 | 8-amino-5'-deoxy-5'-iodoguanosine | - |
Homo sapiens | |
| 2.4.2.1 | 8-Amino-9-benzylguanine | - |
Homo sapiens | |
| 2.4.2.1 | 8-Amino-9-benzylguanine | - |
Plasmodium falciparum | |
| 2.4.2.1 | 8-aminoquinazolinone | - |
Homo sapiens | |
| 2.4.2.1 | 9-(3,4-dihydroxybutyl)guanine | and analogues | Homo sapiens | |
| 2.4.2.1 | 9-(5,5-difluorophosphonopentyl)guanine | - |
Homo sapiens | |
| 2.4.2.1 | 9-(5-phosphonopentyl)guanine | - |
Homo sapiens | |
| 2.4.2.1 | 9-benzylguanine | - |
Homo sapiens | |
| 2.4.2.1 | acyclovir | - |
Cellulomonas sp. | |
| 2.4.2.1 | acyclovir | - |
Homo sapiens | |
| 2.4.2.1 | formycin | - |
Escherichia coli | |
| 2.4.2.1 | formycin B | - |
Bos taurus | |
| 2.4.2.1 | formycin B | - |
Cellulomonas sp. | |
| 2.4.2.1 | formycin B | - |
Escherichia coli | |
| 2.4.2.1 | formycin B | - |
Homo sapiens | |
| 2.4.2.1 | formycin B | - |
Plasmodium falciparum | |
| 2.4.2.1 | formycin B | - |
Plasmodium lophurae | |
| 2.4.2.1 | ganciclovir | - |
Homo sapiens | |
| 2.4.2.1 | N(6)-methyl-formycin A | - |
Escherichia coli | |
| 2.4.2.1 | N(7)-acycloguanosine | - |
Homo sapiens | |
| 2.4.2.1 | N(9)-acycloguanosine | - |
Cellulomonas sp. | |
| 2.4.2.1 | N(9)-acycloguanosine | - |
Homo sapiens | |
| 2.4.2.1 | quinazolinone | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.4.2.1 | additional information | - |
additional information | - |
Homo sapiens | |
| 2.4.2.1 | additional information | - |
additional information | - |
Bos taurus | |
| 2.4.2.1 | additional information | - |
additional information | - |
Escherichia coli | |
| 2.4.2.1 | 0.013 | - |
2-amino-6-mercapto-7-methylpurine | - |
Escherichia coli | |
| 2.4.2.1 | 0.015 | - |
7-methylguanosine | - |
Bos taurus | |
| 2.4.2.1 | 0.027 | - |
7-(beta-D-ribofuranosyl)guanine | - |
Bos taurus | |
| 2.4.2.1 | 0.1 | - |
8-Azaguanine | - |
Bos taurus | |
| 2.4.2.1 | 0.108 | - |
7-(beta-D-ribofuranosyl)guanine | - |
Homo sapiens | |
| 2.4.2.1 | 0.15 | - |
3-(beta-D-ribofuranosyl)adenine | - |
Escherichia coli | |
| 2.4.2.1 | 0.22 | - |
3-(beta-D-ribofuranosyl)hypoxanthine | - |
Bos taurus | |
| 2.4.2.1 | 0.26 | - |
3-(beta-D-ribofuranosyl)hypoxanthine | - |
Escherichia coli | |
| 2.4.2.1 | 0.27 | - |
7-Methylinosine | - |
Escherichia coli | |
| 2.4.2.1 | 0.37 | - |
7-Methylinosine | - |
Homo sapiens | |
| 2.4.2.1 | 0.6 | - |
7-methylguanosine | - |
Bos taurus | |
| 2.4.2.1 | 0.62 | - |
nicotinamide riboside | - |
Escherichia coli | |
| 2.4.2.1 | 0.64 | - |
7-(beta-D-ribofuranosyl)hypoxanthine | - |
Escherichia coli | |
| 2.4.2.1 | 0.661 | - |
8-Azahypoxanthine | - |
Bos taurus | |
| 2.4.2.1 | 0.8 | - |
3-(beta-D-ribofuranosyl)adenine | - |
Bos taurus | |
| 2.4.2.1 | 1.26 | - |
7-(beta-D-ribofuranosyl)hypoxanthine | - |
Homo sapiens | |
| 2.4.2.1 | 1.48 | - |
nicotinamide riboside | - |
Bos taurus | |
| 2.4.2.1 | 1.52 | - |
7-(beta-D-ribofuranosyl)hypoxanthine | - |
Bos taurus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.4.2.1 | 27000 | - |
6 * 27000 | Saccharolobus solfataricus |
| 2.4.2.1 | 58000 | - |
non-denaturing PAGE | Pectobacterium carotovorum |
| 2.4.2.1 | 68000 | - |
- |
Geobacillus stearothermophilus |
| 2.4.2.1 | 68000 | - |
- |
Trypanosoma brucei |
| 2.4.2.1 | 102000 | 108000 | - |
Acholeplasma laidlawii |
| 2.4.2.1 | 114000 | - |
gel filtration | Cellulomonas sp. |
| 2.4.2.1 | 120000 | - |
non-denaturing PAGE | Proteus vulgaris |
| 2.4.2.1 | 138000 | - |
gel filtration | Salmonella enterica subsp. enterica serovar Typhimurium |
| 2.4.2.1 | 138000 | - |
gel filtration | Escherichia coli |
| 2.4.2.1 | 147000 | - |
sucrose density gradient centrifugation | Plasmodium falciparum |
| 2.4.2.1 | 156000 | - |
- |
Klebsiella sp. |
| 2.4.2.1 | 160000 | - |
- |
Saccharolobus solfataricus |
| 2.4.2.1 | 170000 | - |
gel filtration | Serratia marcescens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.1 | additional information | Bos taurus | - |
? | - |
? | |
| 2.4.2.1 | additional information | Homo sapiens | in intact cells, the enzyme functions in the direction of phosphorolysis, leading to degradation of purine nucleosides via coupling with guanase and xanthine oxidase. PNP deficiency is a rare disorder associated with an autosomal recessive form of cellular, but not humoral, immunodeficiency, and comprises about 4% of all cases of severe combined immunodeficiency. Mutations identified in cases of PNP deficiency | ? | - |
? | |
| 2.4.2.1 | additional information | Homo sapiens | enzyme plays a key role in the purine salvage pathway. PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effects on B-cell function | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.4.2.1 | Acholeplasma laidlawii | - |
- |
- |
| 2.4.2.1 | Bacillus cereus | - |
- |
- |
| 2.4.2.1 | Bacillus subtilis | P46354 | - |
- |
| 2.4.2.1 | Bos taurus | P55859 | - |
- |
| 2.4.2.1 | Cellulomonas sp. | - |
- |
- |
| 2.4.2.1 | Escherichia coli | P0ABP8 | - |
- |
| 2.4.2.1 | Fasciola hepatica | - |
- |
- |
| 2.4.2.1 | Geobacillus stearothermophilus | - |
- |
- |
| 2.4.2.1 | Homo sapiens | P00491 | - |
- |
| 2.4.2.1 | Klebsiella aerogenes | - |
- |
- |
| 2.4.2.1 | Klebsiella sp. | - |
- |
- |
| 2.4.2.1 | Micrococcus luteus | - |
- |
- |
| 2.4.2.1 | Mus musculus | - |
- |
- |
| 2.4.2.1 | Pectobacterium carotovorum | - |
- |
- |
| 2.4.2.1 | Plasmodium falciparum | - |
- |
- |
| 2.4.2.1 | Plasmodium lophurae | - |
- |
- |
| 2.4.2.1 | Proteus vulgaris | - |
- |
- |
| 2.4.2.1 | Rattus norvegicus | - |
- |
- |
| 2.4.2.1 | Saccharolobus solfataricus | - |
- |
- |
| 2.4.2.1 | Saccharomyces cerevisiae | Q05788 | - |
- |
| 2.4.2.1 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
| 2.4.2.1 | Serratia marcescens | - |
- |
- |
| 2.4.2.1 | Trypanosoma brucei | - |
- |
- |
| 2.4.2.1 | Trypanosoma cruzi | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.1 | 2-amino-6-mercapto-7-methylpurine ribonucleoside + alpha-D-ribose 1-phosphate | - |
Bos taurus | ? | - |
? | |
| 2.4.2.1 | 2-amino-6-mercapto-7-methylpurine ribonucleoside + alpha-D-ribose 1-phosphate | - |
Escherichia coli | ? | - |
? | |
| 2.4.2.1 | 2-amino-6-mercapto-7-methylpurine ribonucleoside + phosphate | - |
Escherichia coli | alpha-D-ribose 1-phosphate + 2-amino-6-mercapto-7-methylpurine | - |
? | |
| 2.4.2.1 | 3-(beta-D-ribofuranosyl)adenine + alpha-D-ribose 1-phosphate | - |
Bos taurus | ? | - |
? | |
| 2.4.2.1 | 3-(beta-D-ribofuranosyl)adenine + alpha-D-ribose 1-phosphate | - |
Escherichia coli | ? | - |
? | |
| 2.4.2.1 | 3-(beta-D-ribofuranosyl)hyopxanthine + alpha-D-ribose 1-phosphate | - |
Bos taurus | ? | - |
? | |
| 2.4.2.1 | 3-(beta-D-ribofuranosyl)hyopxanthine + alpha-D-ribose 1-phosphate | - |
Escherichia coli | ? | - |
? | |
| 2.4.2.1 | 7-(beta-D-ribofuranosyl)guanine + alpha-D-ribose 1-phosphate | - |
Homo sapiens | ? | - |
? | |
| 2.4.2.1 | 7-(beta-D-ribofuranosyl)guanine + alpha-D-ribose 1-phosphate | - |
Bos taurus | ? | - |
? | |
| 2.4.2.1 | 7-(beta-D-ribofuranosyl)guanine + alpha-D-ribose 1-phosphate | - |
Escherichia coli | ? | - |
? | |
| 2.4.2.1 | 7-(beta-D-ribofuranosyl)hypoxanthine + alpha-D-ribose 1-phosphate | - |
Homo sapiens | ? | - |
? | |
| 2.4.2.1 | 7-(beta-D-ribofuranosyl)hypoxanthine + alpha-D-ribose 1-phosphate | - |
Bos taurus | ? | - |
? | |
| 2.4.2.1 | 7-(beta-D-ribofuranosyl)hypoxanthine + alpha-D-ribose 1-phosphate | - |
Escherichia coli | ? | - |
? | |
| 2.4.2.1 | 7-methyladenosine + phosphate | - |
Homo sapiens | 7-methyladenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 7-methyladenosine + phosphate | - |
Bos taurus | 7-methyladenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 7-methyladenosine + phosphate | - |
Escherichia coli | 7-methyladenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 7-methylguanosine + phosphate | - |
Homo sapiens | 7-methylguanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 7-methylguanosine + phosphate | - |
Bos taurus | 7-methylguanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 7-methylguanosine + phosphate | - |
Escherichia coli | 7-methylguanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 7-methylinosine + phosphate | - |
Cellulomonas sp. | 7-methylhypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 7-methylinosine + phosphate | - |
Homo sapiens | 7-methylhypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 7-methylinosine + phosphate | - |
Bos taurus | 7-methylhypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 7-methylinosine + phosphate | - |
Escherichia coli | 7-methylhypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 8-aminoguanine + alpha-D-ribose 1-phosphate | - |
Homo sapiens | 8-aminoguanosine + phosphate | - |
? | |
| 2.4.2.1 | 8-aminoguanine + alpha-D-ribose 1-phosphate | - |
Bos taurus | 8-aminoguanosine + phosphate | - |
? | |
| 2.4.2.1 | 8-aminoguanine + alpha-D-ribose 1-phosphate | - |
Escherichia coli | 8-aminoguanosine + phosphate | - |
? | |
| 2.4.2.1 | 8-azaguanine + alpha-D-ribose 1-phosphate | - |
Bos taurus | 8-azaguanosine + phosphate | - |
? | |
| 2.4.2.1 | 8-azahypoxanthine + alpha-D-ribose 1-phosphate | - |
Bos taurus | 8-azainosine + phosphate | - |
? | |
| 2.4.2.1 | adenine + deoxyribose 1-phosphate | - |
Homo sapiens | deoxyadenosine + phosphate | - |
r | |
| 2.4.2.1 | adenine + deoxyribose 1-phosphate | - |
Bos taurus | deoxyadenosine + phosphate | - |
r | |
| 2.4.2.1 | adenine + deoxyribose 1-phosphate | - |
Escherichia coli | deoxyadenosine + phosphate | - |
r | |
| 2.4.2.1 | adenosine + phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Mus musculus | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Rattus norvegicus | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Geobacillus stearothermophilus | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Klebsiella aerogenes | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Trypanosoma brucei | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Serratia marcescens | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Trypanosoma cruzi | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Pectobacterium carotovorum | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Acholeplasma laidlawii | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Saccharolobus solfataricus | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Klebsiella sp. | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Fasciola hepatica | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Bos taurus | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Escherichia coli | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | adenosine + phosphate | - |
Bacillus subtilis | adenine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyadenosine + phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | alpha-D-ribose 1-phosphate + adenine | - |
? | |
| 2.4.2.1 | deoxyadenosine + phosphate | - |
Geobacillus stearothermophilus | alpha-D-ribose 1-phosphate + adenine | - |
? | |
| 2.4.2.1 | deoxyadenosine + phosphate | - |
Klebsiella aerogenes | alpha-D-ribose 1-phosphate + adenine | - |
? | |
| 2.4.2.1 | deoxyadenosine + phosphate | - |
Serratia marcescens | alpha-D-ribose 1-phosphate + adenine | - |
? | |
| 2.4.2.1 | deoxyadenosine + phosphate | - |
Trypanosoma cruzi | alpha-D-ribose 1-phosphate + adenine | - |
? | |
| 2.4.2.1 | deoxyadenosine + phosphate | - |
Pectobacterium carotovorum | alpha-D-ribose 1-phosphate + adenine | - |
? | |
| 2.4.2.1 | deoxyadenosine + phosphate | - |
Fasciola hepatica | alpha-D-ribose 1-phosphate + adenine | - |
? | |
| 2.4.2.1 | deoxyadenosine + phosphate | - |
Bos taurus | alpha-D-ribose 1-phosphate + adenine | - |
? | |
| 2.4.2.1 | deoxyadenosine + phosphate | - |
Escherichia coli | alpha-D-ribose 1-phosphate + adenine | - |
? | |
| 2.4.2.1 | deoxyadenosine + phosphate | - |
Bacillus subtilis | alpha-D-ribose 1-phosphate + adenine | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Rattus norvegicus | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Geobacillus stearothermophilus | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Serratia marcescens | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Plasmodium falciparum | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Pectobacterium carotovorum | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Homo sapiens | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Bos taurus | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Escherichia coli | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Saccharomyces cerevisiae | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyguanosine + phosphate | - |
Bacillus subtilis | guanine + alpha-D-deoxyribose 1-phosphate | - |
? | |
| 2.4.2.1 | deoxyinosine + phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
r | |
| 2.4.2.1 | deoxyinosine + phosphate | - |
Geobacillus stearothermophilus | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
r | |
| 2.4.2.1 | deoxyinosine + phosphate | - |
Klebsiella aerogenes | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
r | |
| 2.4.2.1 | deoxyinosine + phosphate | - |
Serratia marcescens | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
r | |
| 2.4.2.1 | deoxyinosine + phosphate | - |
Pectobacterium carotovorum | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
r | |
| 2.4.2.1 | deoxyinosine + phosphate | - |
Homo sapiens | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
r | |
| 2.4.2.1 | deoxyinosine + phosphate | - |
Bos taurus | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
r | |
| 2.4.2.1 | deoxyinosine + phosphate | - |
Escherichia coli | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
r | |
| 2.4.2.1 | deoxyinosine + phosphate | - |
Saccharomyces cerevisiae | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
r | |
| 2.4.2.1 | deoxyinosine + phosphate | - |
Bacillus subtilis | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
r | |
| 2.4.2.1 | guanosine + phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Rattus norvegicus | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Geobacillus stearothermophilus | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Trypanosoma brucei | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Serratia marcescens | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Proteus vulgaris | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Plasmodium falciparum | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Pectobacterium carotovorum | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Saccharolobus solfataricus | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Klebsiella sp. | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Cellulomonas sp. | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Plasmodium lophurae | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Homo sapiens | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Bos taurus | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Escherichia coli | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Saccharomyces cerevisiae | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | - |
Bacillus subtilis | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | guanosine + phosphate | no activity | Acholeplasma laidlawii | guanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Mus musculus | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Rattus norvegicus | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Geobacillus stearothermophilus | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Klebsiella aerogenes | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Trypanosoma brucei | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Serratia marcescens | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Bacillus cereus | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Proteus vulgaris | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Plasmodium falciparum | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Pectobacterium carotovorum | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Saccharolobus solfataricus | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Klebsiella sp. | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Cellulomonas sp. | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Plasmodium lophurae | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Homo sapiens | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Bos taurus | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Escherichia coli | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Saccharomyces cerevisiae | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Bacillus subtilis | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | no activity | Acholeplasma laidlawii | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | additional information | - |
Bos taurus | ? | - |
? | |
| 2.4.2.1 | additional information | in intact cells, the enzyme functions in the direction of phosphorolysis, leading to degradation of purine nucleosides via coupling with guanase and xanthine oxidase. PNP deficiency is a rare disorder associated with an autosomal recessive form of cellular, but not humoral, immunodeficiency, and comprises about 4% of all cases of severe combined immunodeficiency. Mutations identified in cases of PNP deficiency | Homo sapiens | ? | - |
? | |
| 2.4.2.1 | additional information | enzyme plays a key role in the purine salvage pathway. PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effects on B-cell function | Homo sapiens | ? | - |
? | |
| 2.4.2.1 | nicotinamide riboside + phosphate | - |
Homo sapiens | nicotinamide + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | nicotinamide riboside + phosphate | - |
Bos taurus | nicotinamide + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | nicotinamide riboside + phosphate | - |
Escherichia coli | nicotinamide + alpha-D-ribose 1-phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 2.4.2.1 | hexamer | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| 2.4.2.1 | hexamer | - |
Serratia marcescens |
| 2.4.2.1 | hexamer | - |
Escherichia coli |
| 2.4.2.1 | hexamer | - |
Bacillus subtilis |
| 2.4.2.1 | hexamer | 6 * 27000 | Saccharolobus solfataricus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.4.2.1 | additional information | - |
additional information | - |
Homo sapiens | |
| 2.4.2.1 | additional information | - |
additional information | - |
Bos taurus | |
| 2.4.2.1 | additional information | - |
additional information | - |
Escherichia coli | |
| 2.4.2.1 | 0.00018 | - |
5'-deoxy-5'-iodo-9-deazainosine | - |
Homo sapiens | |
| 2.4.2.1 | 0.0002 | - |
8-Amino-9-benzylguanine | - |
Homo sapiens | |
| 2.4.2.1 | 0.0003 | - |
N(6)-methyl-formycin A | - |
Escherichia coli | |
| 2.4.2.1 | 0.0006 | - |
6-benzyloxy-2-chloropurine | - |
Escherichia coli | |
| 2.4.2.1 | 0.0014 | - |
2-chloro-6-(3-phenyl-1-propoxy)purine | - |
Escherichia coli | |
| 2.4.2.1 | 0.0023 | - |
6-chloro-7-deaza-purine 2'-deoxyriboside | - |
Escherichia coli | |
| 2.4.2.1 | 0.0024 | - |
2-amino-6-chloro-7-deazapurine 2'-deoxyriboside | - |
Escherichia coli | |
| 2.4.2.1 | 0.0033 | - |
8-amino-5'-deoxy-5'-iodoguanosine | - |
Homo sapiens | |
| 2.4.2.1 | 0.0046 | - |
formycin B | - |
Escherichia coli | |
| 2.4.2.1 | 0.005 | - |
N(7)-acycloguanosine | - |
Homo sapiens | |
| 2.4.2.1 | 0.005 | - |
formycin | - |
Escherichia coli | |
| 2.4.2.1 | 0.005 | - |
6-amino-7-phenylethinyl-7-deazapurine 2'-deoxyriboside | - |
Escherichia coli | |
| 2.4.2.1 | 0.008 | - |
6-amino-2-chloro-7-deazapurine 2'-deoxyriboside | - |
Escherichia coli | |
| 2.4.2.1 | 0.014 | - |
N(9)-acycloguanosine | - |
Homo sapiens | |
| 2.4.2.1 | 0.018 | - |
5'-deoxy-5'-iodoinosine | - |
Homo sapiens | |
| 2.4.2.1 | 0.09 | - |
acyclovir | - |
Homo sapiens | |
| 2.4.2.1 | 0.323 | - |
quinazolinone | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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