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Literature summary extracted from

  • Arriza, J.L.; Dawson, T.M.; Simerly, R.B.; Martin, L.J.; Caron, M.G.; Snyder, S.H.; Lefkowitz, R.J.
    The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain (1992), J. Neurosci., 12, 4045-4055.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.15 cDNAs encoding beta-ARK 1, 689 amino acids, and beta-ARK 2, 688 amino acids, are cloned, expressed in COS-7 cells and sequenced Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 cytosol
-
 Rattus norvegicus 5829
-
2.7.11.15 additional information subcellular distribution of beta-ARK 1 and 2 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.15 77000
-
 beta-ARK 2, Western blot analysis Rattus norvegicus
2.7.11.15 79800
-
 x * 79800, predicted from the amino acid sequence Rattus norvegicus
2.7.11.15 79900
-
 x * 79900, predicted from the amino acid sequence Rattus norvegicus
2.7.11.15 82000
-
 beta-ARK 1, Western blot analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor Rattus norvegicus general role in the desensitization of synaptic receptors ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Rattus norvegicus involved in homologous desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 additional information Rattus norvegicus general role in the desensitization of synaptic receptors ?
-
 ?
2.7.11.15 additional information Rattus norvegicus general function in desensitizing of many G protein-coupled receptor systems ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Rattus norvegicus P26817
-
-
2.7.11.15 Rattus norvegicus P26817 beta-ARK 1, 2 isoenzymes beta-ARK 1 and 2, adult Sprague-Dawley rats
-
2.7.11.15 Rattus norvegicus P26819
-
-
2.7.11.15 Rattus norvegicus P26819 beta-ARK 2, 2 isoenzymes beta-ARK 1 and 2, adult Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 brain synapses Rattus norvegicus
-
2.7.11.15 brain regional and cellular distribution of beta-ARK 1 and 2 in brain Rattus norvegicus
-
2.7.11.15 neuron beta-ARK 1 and 2 are expressed primarily in neurons distributed throughout the CNS Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor beta2-adrenergic receptor Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor beta-ARK 1 is more active than beta-ARK 2 Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor beta-AR from hamster lung Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor general role in the desensitization of synaptic receptors Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor involved in homologous desensitization of beta-adrenergic receptor Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 additional information general role in the desensitization of synaptic receptors Rattus norvegicus ?
-
 ?
2.7.11.15 additional information general function in desensitizing of many G protein-coupled receptor systems Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.15 ? x * 79800, predicted from the amino acid sequence Rattus norvegicus
2.7.11.15 ? x * 79900, predicted from the amino acid sequence Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 beta-adrenergic receptor kinase 1
-
 Rattus norvegicus
2.7.11.15 beta-adrenergic receptor kinase 2
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.15 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.15 7.5
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
 Rattus norvegicus