Literature summary extracted from

Huang, Q.; Roessner, C.A.; Croteau, R.; Scott, A.I.
Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol (2001), Bioorg. Med. Chem., 9, 2237-2242.

Application

EC Number	Application	Comment	Organism
4.2.3.17	medicine	chemotherapeutic agent against a range of cancers, including ovarian and breast cancer	Taxus brevifolia

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
4.2.3.17	overexpression in Escherichia coli	Taxus brevifolia

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4.2.3.17	geranylgeranyl diphosphate	Taxus brevifolia	catalyzes the first step in taxol biosynthesis	taxa-4,11-diene + diphosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.2.3.17	Taxus brevifolia	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.2.3.17	geranylgeranyl diphosphate	-	Taxus brevifolia	taxa-4(5),11(12)-diene + diphosphate	-	?
4.2.3.17	geranylgeranyl diphosphate	catalyzes the first step in taxol biosynthesis	Taxus brevifolia	taxa-4,11-diene + diphosphate	-	?

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Release 2023.1 (January 2023)