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Literature summary extracted from

  • Lopez, P.; Lacks, S.A.
    A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities (1993), J. Bacteriol., 175, 2214-2220.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.2.25 31000
-
 or tetramer, 4 * or 3 * 31000, bifunctional enzyme with dihydroneopterin aldolase activity and hydroxymethyldihydropterin pyrophosphokinase activity, dihydroneopterin aldolase activity requires the multimeric protein, whereas pyrophosphokinase is expressed by the monomeric form, SDS-PAGE Streptococcus pneumoniae
4.1.2.25 31000
-
 or trimer, 3 * or 4 * 31000, bifunctional enzyme with dihydroneopterin aldolase activity and hydroxymethyldihydropterin pyrophosphokinase activity, dihydroneopterin aldolase activity requires the multimeric protein, whereas pyrophosphokinase is expressed by the monomeric form, SDS-PAGE Streptococcus pneumoniae
4.1.2.25 100000
-
 gel filtration Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.25 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine Streptococcus pneumoniae first enzyme in the folate synthesis pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.25 Streptococcus pneumoniae
-
 bifunctional enzyme with dihydroneopterin aldolase activity and hydroxymethyldihydropterin pyrophosphokinase activity
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.25 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
-
 Streptococcus pneumoniae 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde
-
 ?
4.1.2.25 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine first enzyme in the folate synthesis pathway Streptococcus pneumoniae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.2.25 tetramer or trimer, 3 * or 4 * 31000, bifunctional enzyme with dihydroneopterin aldolase activity and hydroxymethyldihydropterin pyrophosphokinase activity, dihydroneopterin aldolase activity requires the multimeric protein, whereas pyrophosphokinase is expressed by the monomeric form, SDS-PAGE Streptococcus pneumoniae
4.1.2.25 trimer or tetramer, 4 * or 3 * 31000, bifunctional enzyme with dihydroneopterin aldolase activity and hydroxymethyldihydropterin pyrophosphokinase activity, dihydroneopterin aldolase activity requires the multimeric protein, whereas pyrophosphokinase is expressed by the monomeric form, SDS-PAGE Streptococcus pneumoniae