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Literature summary extracted from

  • Sakai, N.; Tanaka, M.; Adachi, S.; Miller, W.L.; Nagahama, Y.
    Rainbow trout cytochrome P-450 c17 (17alpha-hydroxylase/17,20-lyase) (1992), FEBS Lett., 30, 60-64.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.32 full length cDNA clone encoding cytochrome P-450c17 (17alpha-hydrolase/17,20 lyase), expression in mammalian COS-1 cells Oncorhynchus mykiss

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.32 additional information Oncorhynchus mykiss cytochrome P-450c17 mediates both 17alpha-hydroxylase and 17,20 lyase activities in the synthesis of steroid hormones ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.32 Oncorhynchus mykiss
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 rainbow trout
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.32 ovarian follicle ovarian Oncorhynchus mykiss
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.32 17alpha-Hydroxypregnenolone
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 Oncorhynchus mykiss Dehydroepiandrosterone + acetaldehyde DHEA ?
1.14.14.32 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Oncorhynchus mykiss androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 additional information cytochrome P-450c17 mediates both 17alpha-hydroxylase and 17,20 lyase activities in the synthesis of steroid hormones Oncorhynchus mykiss ?
-
 ?