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Literature summary extracted from

  • Burke, D.F.; Laughton, C.A.; Neidle, S.
    Homology modelling of the enzyme P450 17alpha-hydroxylase/17,20-lyase-a taget for prostate cancer chemotherapy-from the crystal structure of P450BM-3 (1997), Anticancer Drug Des., 12, 113-123.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.14.32 medicine homology modelling of the enzyme cytochrome P450 17alpha-hydroxylase/17,20-lyase (P450c17)-a target for prostate cancer chemotherapy-from the crystal structure of P450BM-3 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.32 ketoconazole
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.32 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.32 17alpha-Hydroxypregnenolone
-
Homo sapiens Dehydroepiandrosterone + acetaldehyde DHEA ?
1.14.14.32 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O androstenedione ?