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Literature summary extracted from

  • Barillas, W.; Beerhues, L.
    3-Hydroxybenzoate:coenzyme A ligase and 4-coumarate:coenzyme A ligase from cultured cells of Centaurium erythraea (1997), Planta, 202, 112-116.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.2.1.12 50000
-
 gel filtration Centaurium erythraea
6.2.1.27 50000
-
 gel filtration Centaurium erythraea
6.2.1.37 50000
-
 gel filtration Centaurium erythraea

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.12 ATP + 4-coumarate + CoA Centaurium erythraea 4-coumarate-CoA ligase is the last enzyme of the general phenylpropanoid metabolism, supplying substrates for lignin formation and other individual phenylpropanoid pathways ?
-
 ?
6.2.1.37 ATP + 3-hydroxybenzoate + CoA Centaurium erythraea the enzyme is involved in xanthone biosynthesis AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.12 Centaurium erythraea
-
-
-
6.2.1.27 Centaurium erythraea
-
-
-
6.2.1.37 Centaurium erythraea
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.27 cell suspension culture in the course of culture growth, the activity increases from day 6 and reaches maximum at day 10. This correlates well with the increases in the cell fresh weight and the xanthone content that starts also at day 6 Centaurium erythraea
-
6.2.1.37 cell suspension culture in the course of culture growth, the activities of both enzymes increase from day 6 and reached maxima at day 10. This correlates well with the increases in the cell fresh weight and the xanthone content that starts also at day 6 Centaurium erythraea
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.12 ATP + 4-coumarate + CoA
-
 Centaurium erythraea AMP + diphosphate + 4-coumaroyl-CoA
-
 ?
6.2.1.12 ATP + 4-coumarate + CoA 4-coumarate-CoA ligase is the last enzyme of the general phenylpropanoid metabolism, supplying substrates for lignin formation and other individual phenylpropanoid pathways Centaurium erythraea ?
-
 ?
6.2.1.12 ATP + caffeate + CoA at 4% of the activity relative to 4-coumarate Centaurium erythraea AMP + diphosphate + caffeoyl-CoA
-
 ?
6.2.1.12 ATP + ferulate + CoA 3% of the activity relative to 4-coumarate Centaurium erythraea AMP + diphosphate + feruloyl-CoA
-
 ?
6.2.1.27 ATP + 4-hydroxybenzoate + CoA the bifunctional enzyme is also active with 3-hydroxybenzoate (cf. EC 6.2.1.37). Activity with 4-hydroxybenzoate is 17% of the activity with 3-hydroxybenzoate Centaurium erythraea AMP + diphosphate + 4-hydroxybenzoyl-CoA
-
 ?
6.2.1.27 additional information no activity with 2-hydroxybenzoate, 2,3-dihydroxybenzoate, 3,4-dihydroxybenzoate, 3,5-dihydroxybenzoate and cinnamic acid Centaurium erythraea ?
-
 ?
6.2.1.37 ATP + 3-hydroxybenzoate + CoA the enzyme is involved in xanthone biosynthesis Centaurium erythraea AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
 ?
6.2.1.37 ATP + 3-hydroxybenzoate + CoA the bifunctional enzyme is also active with 4-hydroxybenzoate (cf. EC 6.2.1.27). Activity with 4-hydroxybenzoate is 17% of the activity with 3-hydroxybenzoate Centaurium erythraea AMP + diphosphate + 3-hydroxybenzoyl-CoA
-
 ?
6.2.1.37 additional information no activity with 2-hydroxybenzoate, 2,3-dihydroxybenzoate, 3,4-dihydroxybenzoate, 3,5-dihydroxybenzoate and cinnamic acid Centaurium erythraea ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.2.1.12 30
-
-
 Centaurium erythraea
6.2.1.27 20 30
-
 Centaurium erythraea
6.2.1.37 20 30
-
 Centaurium erythraea

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.12 6.5
-
-
 Centaurium erythraea
6.2.1.27 7
-
-
 Centaurium erythraea
6.2.1.37 7
-
-
 Centaurium erythraea