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Literature summary extracted from

  • De Deken, X.; Wang, D.; Many, M.C.; Costagliola, S.; Libert, F.; Vassart, G.; Dumont, J.E.; Miot, F.
    Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family (2000), J. Biol. Chem., 275, 23227-23233.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.3.1 additional information upregulated by agents activationg cAMP pathway Sus scrofa
1.6.3.1 additional information upregulated by agents activationg cAMP pathway Canis lupus familiaris

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.6.3.1
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.3.1 apical plasma membrane
-
 Sus scrofa 16324
-
1.6.3.1 apical plasma membrane
-
 Canis lupus familiaris 16324
-
1.6.3.1 apical plasma membrane seven transmembrane regions found Homo sapiens 16324
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.6.3.1 Ca2+ required for full activity Sus scrofa
1.6.3.1 Ca2+ required for full activity Canis lupus familiaris
1.6.3.1 Ca2+ required for full activity Homo sapiens
1.6.3.1 Ca2+ regulates enzyme activity Sus scrofa
1.6.3.1 Ca2+ regulates enzyme activity Canis lupus familiaris
1.6.3.1 Ca2+ regulates enzyme activity Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.6.3.1 177000
-
 calculated from DNA sequence Sus scrofa
1.6.3.1 180000
-
 SDS-PAGE Sus scrofa
1.6.3.1 180000
-
 SDS-PAGE Canis lupus familiaris
1.6.3.1 180000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.3.1 NAD(P)H + H+ + O2 Caenorhabditis elegans
-
 NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 Sus scrofa production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 Canis lupus familiaris production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 Homo sapiens production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Caenorhabditis elegans O61213 high sequence similarities to mammalian proteins
-
1.6.3.1 Canis lupus familiaris
-
-
-
1.6.3.1 Homo sapiens Q9NRD8
-
-
1.6.3.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 additional information
-
 Homo sapiens
-
1.6.3.1 additional information different tissues screened for ThOX2, except for a weak signal in stomach ThOX2 in exclusively found in thyroid cells Canis lupus familiaris
-
1.6.3.1 stomach very weak signal Canis lupus familiaris
-
1.6.3.1 thyroid gland
-
 Sus scrofa
-
1.6.3.1 thyroid gland
-
 Canis lupus familiaris
-
1.6.3.1 thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.3.1 NAD(P)H + H+ + O2
-
 Sus scrofa NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2
-
 Canis lupus familiaris NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2
-
 Homo sapiens NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2
-
 Caenorhabditis elegans NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Sus scrofa NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Canis lupus familiaris NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Homo sapiens NAD(P)+ + H2O2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.3.1 FAD
-
 Sus scrofa
1.6.3.1 FAD binding site Homo sapiens